{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kuran G"],"funding":["Health Sciences University Scientific Research Projects Coordination Unit"],"pagination":["7666"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12946323"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["Laryngeal cancer has a poor prognosis and invasive character. Despite recent technological advances, laryngeal cancer remains challenging with a low survival rate. Artocarpus lakoocha Roxb. (AL) is rich in oxyresveratrol with antioxidant, cytotoxic, and anti-inflammatory properties This study aimed to determine the total phenolic content, antioxidant capacity and in-vitro anticancer effects of AL on laryngeal cancer cell lines. Total phenolic content and antioxidant activity of AL was evaluated using Folin-Ciocalte and DPPH tests. Cytotoxic and antiproliferative effects were measured with MTT and live-dead assays, while CASP-3, BAX, and BCL-2 expressions were analyzed via qRT-PCR and western blotting. Cell migration inhibition was determined by scratch-wound healing assay. The total phenol"],"journal":["Scientific reports"],"pubmed_title":["The antioxidant capacity and in-vitro anticancer effects of Artocarpus lakoocha Roxb. against laryngeal cancer cells."],"pmcid":["PMC12946323"],"funding_grant_id":["2022/136"],"pubmed_authors":["Kuran G","Canatar I","Ozdas S","Ozdas T","Baldemir Kilic A"],"additional_accession":[]},"is_claimable":false,"name":"The antioxidant capacity and in-vitro anticancer effects of Artocarpus lakoocha Roxb. against laryngeal cancer cells.","description":"Laryngeal cancer has a poor prognosis and invasive character. Despite recent technological advances, laryngeal cancer remains challenging with a low survival rate. Artocarpus lakoocha Roxb. (AL) is rich in oxyresveratrol with antioxidant, cytotoxic, and anti-inflammatory properties This study aimed to determine the total phenolic content, antioxidant capacity and in-vitro anticancer effects of AL on laryngeal cancer cell lines. Total phenolic content and antioxidant activity of AL was evaluated using Folin-Ciocalte and DPPH tests. Cytotoxic and antiproliferative effects were measured with MTT and live-dead assays, while CASP-3, BAX, and BCL-2 expressions were analyzed via qRT-PCR and western blotting. Cell migration inhibition was determined by scratch-wound healing assay. The total phenol","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T22:17:07.422Z","creation":"2026-07-12T03:08:58.045Z"},"accession":"S-EPMC12946323","cross_references":{"pubmed":["41654614"],"doi":["10.1038/s41598-026-38501-y"]}}