{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Fernandez-Garnacho EM"],"funding":["Interreg","Agència de Gestió d'Ajuts Universitaris i de Recerca","Agència de Gestió d'Ajuts Universitaris i de Recerca","Ministerio de Ciencia e Innovación","Institució Catalana de Recerca i Estudis Avançats","Fundació la Marató de TV3","Centro de Investigación Biomédica en Red de Cáncer"],"pagination":["7655"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12946376"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["MALAT1 is a long non-coding RNA (lncRNA) with altered expression in many cancers but poorly studied in B-cell neoplasms like mantle cell lymphoma (MCL), a very aggressive B-cell lymphoma. To elucidate the role of MALAT1 in MCL we have investigated its expression in 219 primary tumors using microarray data. We also analyzed the expression of its natural antisense transcript (TALAM1), which is key for the processing of MALAT1 RNA to its active isoform. High expression of MALAT1/TALAM1 lncRNAs was consistently linked to favorable clinical behavior in MCL, independently of other alterations previously described to influence MCL prognosis. In concordance with the observed clinical association, we found that the increased expression of these lncRNAs was inversely associated with gene signatures "],"journal":["Scientific reports"],"pubmed_title":["The expression of MALAT1 long non-coding RNA is associated with good prognosis in mantle cell lymphoma."],"pmcid":["PMC12946376"],"funding_grant_id":["POCTEFA program (IMLINFO EFA281/16 and THERAVLINFO EFA123/1","Suport Grups de Recerca AGAUR (2021-SGR-01294)","Suport Grups de Recerca AGAUR (2021-SGR-01172)","Suport Grups de Recerca AGAUR ( 2021-SGR-01343)","Spanish Ministry of Science, Innovation and Universities (MCIN) & European Regional Development Fund (ERDF, “A way of making Europe”) PID2021-123054OB-I00","(“projecte finançat per Fundació La Marató de TV3”) 201920-30","Spanish Ministry of Science, Innovation and Universities (MCIN) & European Regional Development Fund (ERDF, \"A way of making Europe\") PID2021-124894OB-I00","Academia Researcher of the \"Institució Catalana de Recerca i Estudis Avançats\" (ICREA) of the Generalitat de Catalunya","Suport Grups de Recerca AGAUR  (2021-SGR-01294)","AGAUR 2018 FIB00696, Generalitat de Catalunya and FSE (European Union)","(“projecte finançat per Fundació La Marató de TV3”) TAIFOL project, 201933-30","(\"projecte finançat per Fundació La Marató de TV3\") TAIFOL project, 201933-30","(\"projecte finançat per Fundació La Marató de TV3\") 201920-30","Spanish Ministry of Science, Innovation and Universities (MCIN) & European Regional Development Fund (ERDF, “A way of making Europe”) PID2021-124894OB-I00","Academia Researcher of the "Institució Catalana de Recerca i Estudis Avançats" (ICREA) of the Generalitat de Catalunya","CIBERONC (ONCG09/2025)","Spanish Ministry of Science, Innovation and Universities (MCIN) & European Regional Development Fund (ERDF, \"A way of making Europe\") PID2021-123054OB-I00"],"pubmed_authors":["Araujo-Ayala F","Bea S","Demajo S","Amador V","Colomer D","Rivero A","Martinez-Munoz C","Clot G","Campo E","Jares P","Mozas P","Martin-Subero JI","Fernandez-Garnacho EM","Hernandez L","Martinez-Farran A","De Bolos A","Lopez C","Salaverria I","Lopez-Guillermo A","Nadeu F","Gine E","Valero JG","Perez-Galan P"],"additional_accession":[]},"is_claimable":false,"name":"The expression of MALAT1 long non-coding RNA is associated with good prognosis in mantle cell lymphoma.","description":"MALAT1 is a long non-coding RNA (lncRNA) with altered expression in many cancers but poorly studied in B-cell neoplasms like mantle cell lymphoma (MCL), a very aggressive B-cell lymphoma. To elucidate the role of MALAT1 in MCL we have investigated its expression in 219 primary tumors using microarray data. We also analyzed the expression of its natural antisense transcript (TALAM1), which is key for the processing of MALAT1 RNA to its active isoform. High expression of MALAT1/TALAM1 lncRNAs was consistently linked to favorable clinical behavior in MCL, independently of other alterations previously described to influence MCL prognosis. In concordance with the observed clinical association, we found that the increased expression of these lncRNAs was inversely associated with gene signatures ","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T22:23:11.326Z","creation":"2026-07-13T03:07:07.254Z"},"accession":"S-EPMC12946376","cross_references":{"pubmed":["41654636"],"doi":["10.1038/s41598-026-38971-0"]}}