{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Breville G"],"funding":["Swiss National Science Foundation"],"pagination":["261-273"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12946607"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["99(1)"],"pubmed_abstract":["<h4>Objective</h4>Hepatocyte growth factor (HGF) binds exclusively the c-Met surface receptor, and the HGF/c-Met axis regulates T cell function in autoimmune diseases. We analyzed c-Met expression on human CD4 T cells in the blood and cerebrospinal fluid (CSF) from patients with multiple sclerosis (MS) versus non-inflammatory neurological disease (NIND), to better understand the role of CD4 T cells in MS.<h4>Methods</h4>We recruited 34 untreated MS patients (age 28-44 years) and 13 NIND (age 34-51 years) who underwent paired blood and CSF sampling at the time of diagnosis work-up. Phenotypic and functional CD4 T cells characterization was determined by flow cytometry and bulk RNA sequencing. Adhesion and transmigration capacities were studied to further characterize the function of c-Met<s"],"journal":["Annals of neurology"],"pubmed_title":["Pro-Inflammatory c-Met&lt;sup&gt;+&lt;/sup&gt; CD4 T Cells in Multiple Sclerosis."],"pmcid":["PMC12946607"],"funding_grant_id":["P500PM_222181","310030","310030_214931","214931"],"pubmed_authors":["Rezk A","Benkhoucha M","Lalive PH","Senoner I","Breville G","Bar-Or A","Tran NL"],"additional_accession":[]},"is_claimable":false,"name":"Pro-Inflammatory c-Met&lt;sup&gt;+&lt;/sup&gt; CD4 T Cells in Multiple Sclerosis.","description":"<h4>Objective</h4>Hepatocyte growth factor (HGF) binds exclusively the c-Met surface receptor, and the HGF/c-Met axis regulates T cell function in autoimmune diseases. We analyzed c-Met expression on human CD4 T cells in the blood and cerebrospinal fluid (CSF) from patients with multiple sclerosis (MS) versus non-inflammatory neurological disease (NIND), to better understand the role of CD4 T cells in MS.<h4>Methods</h4>We recruited 34 untreated MS patients (age 28-44 years) and 13 NIND (age 34-51 years) who underwent paired blood and CSF sampling at the time of diagnosis work-up. Phenotypic and functional CD4 T cells characterization was determined by flow cytometry and bulk RNA sequencing. Adhesion and transmigration capacities were studied to further characterize the function of c-Met<s","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-16T22:27:29.195Z","creation":"2026-07-11T03:11:58.83Z"},"accession":"S-EPMC12946607","cross_references":{"pubmed":["41002109"],"doi":["10.1002/ana.78035"]}}