biostudies-literatureUnknown26(1)Miki KA Grant-in-Aid for Clinical Research from the National Hospital Organization<h4>Background</h4>Oxygen uptake (V'_O2) obtained from expiratory gas analysis is generally calculated using minute ventilation (V'_E) and the inspired‒expired mean oxygen (O₂) concentration difference (ΔF_O2) during cardiopulmonary exercise testing (CPET). We have reported that ΔF_O2, which is associated with ventilatory efficiency, is independent of V'_E at peak exercise and affects exercise tolerance in respiratory diseases other than idiopathic pulmonary fibrosis (IPF). We hypothesized that similar results are obtained in IPF, and that ΔF_O2 is a prognostic factor for survival in IPF.<h4>Methods</h4>Forty-three patients with IPF, who underwent CPET with blood gas analysis were enrolled from our database.<h4>Results<BMC pulmonary medicine102https://www.ebi.ac.uk/biostudies/studies/S-EPMC12947475biostudies-literatureExercise alveolar oxygen extraction rate reflects ventilatory efficiency and predicts outcomes in idiopathic pulmonary fibrosis.PMC12947475Tsujino KKida HMiki KNagata YMihashi YNishijima RSugisawa KNii TMatsuki TfalseExercise alveolar oxygen extraction rate reflects ventilatory efficiency and predicts outcomes in idiopathic pulmonary fibrosis.<h4>Background</h4>Oxygen uptake (V'_O2) obtained from expiratory gas analysis is generally calculated using minute ventilation (V'_E) and the inspired‒expired mean oxygen (O₂) concentration difference (ΔF_O2) during cardiopulmonary exercise testing (CPET). We have reported that ΔF_O2, which is associated with ventilatory efficiency, is independent of V'_E at peak exercise and affects exercise tolerance in respiratory diseases other than idiopathic pulmonary fibrosis (IPF). We hypothesized that similar results are obtained in IPF, and that ΔF_O2 is a prognostic factor for survival in IPF.<h4>Methods</h4>Forty-three patients with IPF, who underwent CPET with blood gas analysis were enrolled from our database.<h4>Results<2025-01-01T00:00:00Z2025 Dec2026-07-16T22:25:03.022Z2026-07-11T03:12:00.906ZS-EPMC129474754141388210.1186/s12890-025-04064-3