biostudies-literatureUnknown16Zhang B<h4>Background</h4>Respiratory failure (RF) is the leading cause of death in chronic obstructive pulmonary disease (COPD), yet reliable biomarkers for early risk stratification remain unclear. Circulating C-reactive protein (CRP) reflects systemic inflammation, but its prognostic value for incident RF in COPD is controversial.<h4>Methods</h4>A total of 38 933 patients from the UK Biobank with the ratio of Forced Expiratory Volume in 1 second to Forced Vital Capacity (FEV₁/FVC) < 0.70 but without RF at baseline were included, and a maximum of 17.87 years of follow-up was conducted. Participants were divided into five subgroups based on serum CRP concentration. Kaplan-Meier survival analysis was utilised to assess the correlation between CRP stratification, incident RF, all-cause mortality, and COPD-induced mortality. The dose-response relationship between CRP concentration and incident RF was investigated using Cox proportional hazards regression.<h4>Results</h4>Kaplan-Meier curves showed statistically significant differences in RF across all subgroups throughout the entire follow-up period. Additionally, significant differences were observed between groups concerning all-cause mortality and COPD-induced mortality as well. The Cox proportional hazards model demonstrated a clear dose-response relationship between CRP concentration and RF, even after adjustment for several clinical covariates and systemic inflammation index.<h4>Conclusions</h4>Serum CRP concentration may forecast a high risk of incident RF in patients with COPD, indicating further research on the threshold.Journal of global health04061https://www.ebi.ac.uk/biostudies/studies/S-EPMC12947716biostudies-literatureC-reactive protein predicts respiratory failure in chronic obstructive pulmonary disease: a cohort analysis from the UK Biobank.PMC12947716Zhao RJiang QChen YZhang BDai ZfalseC-reactive protein predicts respiratory failure in chronic obstructive pulmonary disease: a cohort analysis from the UK Biobank.<h4>Background</h4>Respiratory failure (RF) is the leading cause of death in chronic obstructive pulmonary disease (COPD), yet reliable biomarkers for early risk stratification remain unclear. Circulating C-reactive protein (CRP) reflects systemic inflammation, but its prognostic value for incident RF in COPD is controversial.<h4>Methods</h4>A total of 38 933 patients from the UK Biobank with the ratio of Forced Expiratory Volume in 1 second to Forced Vital Capacity (FEV₁/FVC) < 0.70 but without RF at baseline were included, and a maximum of 17.87 years of follow-up was conducted. Participants were divided into five subgroups based on serum CRP concentration. Kaplan-Meier survival analysis was utilised to assess the correlation between CRP stratification, incident RF, all-cause mortality, and COPD-induced mortality. The dose-response relationship between CRP concentration and incident RF was investigated using Cox proportional hazards regression.<h4>Results</h4>Kaplan-Meier curves showed statistically significant differences in RF across all subgroups throughout the entire follow-up period. Additionally, significant differences were observed between groups concerning all-cause mortality and COPD-induced mortality as well. The Cox proportional hazards model demonstrated a clear dose-response relationship between CRP concentration and RF, even after adjustment for several clinical covariates and systemic inflammation index.<h4>Conclusions</h4>Serum CRP concentration may forecast a high risk of incident RF in patients with COPD, indicating further research on the threshold.2026-01-01T00:00:00Z2026 Feb2026-07-16T22:20:26.265Z2026-07-11T03:12:10.219ZS-EPMC129477164175781210.7189/jogh.16.04061