{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yin J"],"funding":["Fundamental Research Funds of the Central Universities, China","Development and Reform Commission of Jilin Province","National Natural Science Foundation of China","Science and Technology Department of Jilin Province","National Key Research and Development Program of China"],"pagination":["e08107"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12948188"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(12)"],"pubmed_abstract":["The metabolic reprogramming of immunosuppressive tumor microenvironment (ITME) greatly influences the anti-tumor immunity. Bioinformatic analysis demonstrates that indoleamine 2,3-dioxygenase 1 and 3-hydroxy-3-methylglutaryl coenzyme A reductase (key enzymes of kynurenine (Kyn) and cholesterol metabolism, respectively), are overexpressed in human colon adenocarcinoma tissues. Herein, biomimetic and pH/ROS dual-responsive nanoparticles (PTSK@CRM) loaded with simvastatin and kynureninase (KYNase) are prepared to regulate Kyn and cholesterol metabolism, thereby enhancing the immunotherapeutic efficacy of PD-1 antibody (αPD-1). The monodisperse spherical PTSK@CRM is stable at pH 7.4, while it can release simvastatin and KYNase under low pH and high H<sub>2</sub>O<sub>2</sub> concentration. PTS"],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["Regulating Tumor Metabolic Reprogramming with Biomimetic Co-Delivery of Simvastatin and Kynureninase for Immunotherapy."],"pmcid":["PMC12948188"],"funding_grant_id":["2024-JCXK-11","U24A20365","2023C015","2023-JCXK-25","2024YFE0213800","32271319","YDZJ202401328ZYTS","52203168"],"pubmed_authors":["Liu Z","Zhao S","Sun S","Li Q","Yang S","Yin J"],"additional_accession":[]},"is_claimable":false,"name":"Regulating Tumor Metabolic Reprogramming with Biomimetic Co-Delivery of Simvastatin and Kynureninase for Immunotherapy.","description":"The metabolic reprogramming of immunosuppressive tumor microenvironment (ITME) greatly influences the anti-tumor immunity. Bioinformatic analysis demonstrates that indoleamine 2,3-dioxygenase 1 and 3-hydroxy-3-methylglutaryl coenzyme A reductase (key enzymes of kynurenine (Kyn) and cholesterol metabolism, respectively), are overexpressed in human colon adenocarcinoma tissues. Herein, biomimetic and pH/ROS dual-responsive nanoparticles (PTSK@CRM) loaded with simvastatin and kynureninase (KYNase) are prepared to regulate Kyn and cholesterol metabolism, thereby enhancing the immunotherapeutic efficacy of PD-1 antibody (αPD-1). The monodisperse spherical PTSK@CRM is stable at pH 7.4, while it can release simvastatin and KYNase under low pH and high H<sub>2</sub>O<sub>2</sub> concentration. PTS","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T22:17:00.897Z","creation":"2026-07-12T03:08:51.436Z"},"accession":"S-EPMC12948188","cross_references":{"pubmed":["41432057"],"doi":["10.1002/advs.202508107"]}}