{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xu H"],"funding":["National Key Research, Development Program of China","Joint Research Program of State Key Laboratory of Agricultural and Forestry Biosecurity","Funding for a World-Class Plant Protection Discipline","Natural Science Foundation of Fujian","National Natural Science Foundation of China -Youth Fund Project","National Natural Science Foundation-Outstanding Youth Foundation"],"pagination":["e11907"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12948193"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(12)"],"pubmed_abstract":["Enhancing nitrogen-use efficiency is essential for boosting crop yields and advancing sustainable agriculture, particularly in the absence of synthetic fertilizers. Despite the inherent nitrogen-fixation capacity of the staple legume crop soybean (Glycine max) by symbiotic rhizobia, improving nitrogen use has been challenging. Here, a role for the auxin-efflux transporters PIN3a and PIN3b in soybean nitrate acquisition is uncovered. PIN3a/b localizes to the plasma membrane, and high environmental nitrate induces PIN3a degradation and its accumulation at cell junctions. Disrupting PIN3 homologs results in auxin over-accumulation, impairs pavement-cell polarity, and enhances signaling via the transcription factors ARF and STF3/4. These transcription factors separately bind to and activate th"],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["Soybean Auxin Transporter PIN3 Regulates Nitrate Acquisition to Improve Nitrogen Use and Seed Traits."],"pmcid":["PMC12948193"],"funding_grant_id":["SKLJPR2505","2022YFA0912100","2023J01482","32300277","32222009","2022J01161","133-725025010B"],"pubmed_authors":["Wu K","Han Q","Chen J","Huang L","Xu H","Wang J","Shi X","Wang M","Liu Y","Huang S","Tu T","Chen Z","Zhang Y","Wang T","Lin G","Gao Z","Chen X"],"additional_accession":[]},"is_claimable":false,"name":"Soybean Auxin Transporter PIN3 Regulates Nitrate Acquisition to Improve Nitrogen Use and Seed Traits.","description":"Enhancing nitrogen-use efficiency is essential for boosting crop yields and advancing sustainable agriculture, particularly in the absence of synthetic fertilizers. Despite the inherent nitrogen-fixation capacity of the staple legume crop soybean (Glycine max) by symbiotic rhizobia, improving nitrogen use has been challenging. Here, a role for the auxin-efflux transporters PIN3a and PIN3b in soybean nitrate acquisition is uncovered. PIN3a/b localizes to the plasma membrane, and high environmental nitrate induces PIN3a degradation and its accumulation at cell junctions. Disrupting PIN3 homologs results in auxin over-accumulation, impairs pavement-cell polarity, and enhances signaling via the transcription factors ARF and STF3/4. These transcription factors separately bind to and activate th","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T22:28:57.216Z","creation":"2026-07-11T03:12:08.503Z"},"accession":"S-EPMC12948193","cross_references":{"pubmed":["41250913"],"doi":["10.1002/advs.202511907"]}}