{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shi J"],"funding":["Fundamental Research Funds for the Central Universities","National Key R&D Program of China","Agricultural Gene Editing Platform Technology and Breeding R&D Program of Hubei","National Natural Science Foundation of China","Biological Breeding-National Science and Technology Major Project","National Key Research and Development Program of China"],"pagination":["e13762"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12948261"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(12)"],"pubmed_abstract":["The chromatin remodeler nucleosome assembly protein 1-like 4 (Nap1L4) is highly expressed in megakaryocyte-erythroid progenitors (MEPs) and erythroid cells. Mutations, deletions, and aberrant expressions of Nap1L4 are observed in diseases such as acute myeloid leukemia (AML). However, the roles of Nap1l4a in erythropoiesis and related diseases, as well as the underlying mechanisms, remain unknown. Here, it is demonstrated that zebrafish nap1l4a homozygous mutants (nap1l4a<sup>-/-</sup>) are more sensitive to hypoxia stress during the early embryonic stage and exhibit impaired primitive erythropoiesis. Mechanistically, zebrafish Nap1l4a interacts with the erythropoietic transcription factors (TFs) Scl and Klf1, and recruits the histone variant H2A.Z. This interaction remodels the cis-regula"],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["Nap1L4a Cooperates with Scl/Klf1 to Recruit H2A.Z in Mediating Interactions Among Cis-Regulatory Elements and Transcription Required for Primitive Erythropoiesis in Zebrafish."],"pmcid":["PMC12948261"],"funding_grant_id":["2023ZD04065","32500719","32570762","2662025PY018","2024BBA001","2022YFF1000302","2662025DKPY005"],"pubmed_authors":["Li G","Fang Y","Shen Z","Lai F","Zhang X","Wang H","Liu JX","Shi J","Wang Y","Li K","Liu W"],"additional_accession":[]},"is_claimable":false,"name":"Nap1L4a Cooperates with Scl/Klf1 to Recruit H2A.Z in Mediating Interactions Among Cis-Regulatory Elements and Transcription Required for Primitive Erythropoiesis in Zebrafish.","description":"The chromatin remodeler nucleosome assembly protein 1-like 4 (Nap1L4) is highly expressed in megakaryocyte-erythroid progenitors (MEPs) and erythroid cells. Mutations, deletions, and aberrant expressions of Nap1L4 are observed in diseases such as acute myeloid leukemia (AML). However, the roles of Nap1l4a in erythropoiesis and related diseases, as well as the underlying mechanisms, remain unknown. Here, it is demonstrated that zebrafish nap1l4a homozygous mutants (nap1l4a<sup>-/-</sup>) are more sensitive to hypoxia stress during the early embryonic stage and exhibit impaired primitive erythropoiesis. Mechanistically, zebrafish Nap1l4a interacts with the erythropoietic transcription factors (TFs) Scl and Klf1, and recruits the histone variant H2A.Z. This interaction remodels the cis-regula","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T22:24:58.774Z","creation":"2026-07-11T03:12:00.089Z"},"accession":"S-EPMC12948261","cross_references":{"pubmed":["41387107"],"doi":["10.1002/advs.202513762"]}}