{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang J"],"funding":["The Research Grants Council, Hong Kong","Shenzhen Science and Technology Innovation Commission"],"pagination":["236"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12948957"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(1)"],"pubmed_abstract":["Liver resection is the primary curative treatment for early-stage hepatocellular carcinoma (HCC); however, high recurrence rates remain a major challenge in the absence of effective prognostic and preventive strategies. Here, we identified surgery-induced C-C motif chemokine ligand 11 (CCL11) as a pivotal driver of HCC recurrence through dual mechanisms of immunosuppression and tumor invasiveness. Elevated postoperative circulating CCL11 levels correlated strongly with HCC recurrence and poorer survival, and their integration with clinical parameters enhanced the predictive accuracy of HCC recurrence. Mechanistically, hepatic injury-induced CCL11 recruited immunosuppressive CCR5<sup>+</sup>CD206<sup>+</sup> M2-like macrophages into the residual liver. These macrophages exhibited enhanced P"],"journal":["Cell death & disease"],"pubmed_title":["CCL11 promotes hepatocellular carcinoma recurrence after surgery by potentiating immunosuppressive CCR5 + CD206 + M2-like macrophages and promoting tumor invasiveness."],"pmcid":["PMC12948957"],"funding_grant_id":["JCYJ20210324114403010","JCYJ20240813113042055"],"pubmed_authors":["Zeng S","Liu J","Yeung OW","Hu Z","Ng KT","Wang J","Cheung TT","Man K","Yang X","Qiu W","Ding T","Pang L","Wang Z"],"additional_accession":[]},"is_claimable":false,"name":"CCL11 promotes hepatocellular carcinoma recurrence after surgery by potentiating immunosuppressive CCR5 + CD206 + M2-like macrophages and promoting tumor invasiveness.","description":"Liver resection is the primary curative treatment for early-stage hepatocellular carcinoma (HCC); however, high recurrence rates remain a major challenge in the absence of effective prognostic and preventive strategies. Here, we identified surgery-induced C-C motif chemokine ligand 11 (CCL11) as a pivotal driver of HCC recurrence through dual mechanisms of immunosuppression and tumor invasiveness. Elevated postoperative circulating CCL11 levels correlated strongly with HCC recurrence and poorer survival, and their integration with clinical parameters enhanced the predictive accuracy of HCC recurrence. Mechanistically, hepatic injury-induced CCL11 recruited immunosuppressive CCR5<sup>+</sup>CD206<sup>+</sup> M2-like macrophages into the residual liver. These macrophages exhibited enhanced P","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T23:12:20.152Z","creation":"2026-07-12T03:11:10.943Z"},"accession":"S-EPMC12948957","cross_references":{"pubmed":["41714328"],"doi":["10.1038/s41419-026-08508-4"]}}