{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rojas EJ"],"funding":["National Center for Advancing Translational Sciences","NCATS NIH HHS","Chan Zuckerberg Biohub","UCSF Center for Maternal Fetal Medicine","NIH NCI"],"pagination":["87"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12949016"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(1)"],"pubmed_abstract":["Sacrococcygeal teratomas (SCTs) are the most common neonatal tumors, yet their cellular origins, clinical stratification, and sex bias-occurring three times more in XX than XY individuals-remain poorly understood. To address these gaps, we examined six postnatal (one male and five female) and two prenatal (both female) SCTs by single nuclei RNA-seq and spatial transcriptomics. We identified five broad cellular lineages in SCTs: stroma, epithelia, endothelia, neuroectoderm, and immune. The transcriptomes and lineage compositions showed significant heterogeneity, which offer a framework for future molecular stratification. SCTs are thought to originate from and be propagated by pluripotent cells, notably however, we did not detect these populations. Among female tumors, a subset of cells exh"],"journal":["NPJ precision oncology"],"pubmed_title":["Single nuclei and spatial profiling of sacrococcygeal teratomas reveals cellular composition and X inactivation heterogeneity."],"pmcid":["PMC12949016"],"funding_grant_id":["F31-CA284719","UL1 TR001872"],"pubmed_authors":["Bagrodia A","Vu L","Rojas EJ","Derderian SC","Laird DJ","Huang BJ","Pena D","Giannikou K","Cho SJ","Cordero MA","MacKenzie TC"],"additional_accession":[]},"is_claimable":false,"name":"Single nuclei and spatial profiling of sacrococcygeal teratomas reveals cellular composition and X inactivation heterogeneity.","description":"Sacrococcygeal teratomas (SCTs) are the most common neonatal tumors, yet their cellular origins, clinical stratification, and sex bias-occurring three times more in XX than XY individuals-remain poorly understood. To address these gaps, we examined six postnatal (one male and five female) and two prenatal (both female) SCTs by single nuclei RNA-seq and spatial transcriptomics. We identified five broad cellular lineages in SCTs: stroma, epithelia, endothelia, neuroectoderm, and immune. The transcriptomes and lineage compositions showed significant heterogeneity, which offer a framework for future molecular stratification. SCTs are thought to originate from and be propagated by pluripotent cells, notably however, we did not detect these populations. Among female tumors, a subset of cells exh","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-16T23:33:24.744Z","creation":"2026-07-12T03:11:24.746Z"},"accession":"S-EPMC12949016","cross_references":{"pubmed":["41565739"],"doi":["10.1038/s41698-025-01262-4"]}}