{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Collins E"],"funding":["NEI NIH HHS"],"pagination":["e13321"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12949407"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["29(1)"],"pubmed_abstract":["<h4>Objective</h4>To investigate the level of pro-inflammatory cytokines in aqueous humor from ADAMTS10-mutant research Beagles at an early stage of open-angle glaucoma (OAG).<h4>Animals studied</h4>Twenty-four research Beagles were enrolled into this case-controlled study. Three groups of ADAMTS10-mutant research Beagles were enrolled in this study: (1) Intraocular pressure (IOP) 15-25 mmHg (normotensive IOP), (2) IOP 25-30 mmHg, and (3) IOP 30-36 mmHg. An unaffected control group of Beagles that were either ADAMTS10-wildtype (WT) or heterozygote-carrier with normotensive IOPs were also enrolled.<h4>Procedures</h4>Aqueous humor samples were collected and analyzed for 16 pro-inflammatory cytokines using the Canine Cytokine SpikeMix and target mass spectrometry via multiple reaction monitor"],"journal":["Veterinary ophthalmology"],"pubmed_title":["Pro-Inflammatory Cytokines in Aqueous Humor From ADAMTS10-Mutant Beagles at an Early Stage of Open-Angle Glaucoma."],"pmcid":["PMC12949407"],"funding_grant_id":["R01 EY025752","R01 EY032478"],"pubmed_authors":["Harman CD","Collins E","Love KR","de Linde Henriksen M","Mehaffy C","Komaromy AM","Jacobson AL"],"additional_accession":[]},"is_claimable":false,"name":"Pro-Inflammatory Cytokines in Aqueous Humor From ADAMTS10-Mutant Beagles at an Early Stage of Open-Angle Glaucoma.","description":"<h4>Objective</h4>To investigate the level of pro-inflammatory cytokines in aqueous humor from ADAMTS10-mutant research Beagles at an early stage of open-angle glaucoma (OAG).<h4>Animals studied</h4>Twenty-four research Beagles were enrolled into this case-controlled study. Three groups of ADAMTS10-mutant research Beagles were enrolled in this study: (1) Intraocular pressure (IOP) 15-25 mmHg (normotensive IOP), (2) IOP 25-30 mmHg, and (3) IOP 30-36 mmHg. An unaffected control group of Beagles that were either ADAMTS10-wildtype (WT) or heterozygote-carrier with normotensive IOPs were also enrolled.<h4>Procedures</h4>Aqueous humor samples were collected and analyzed for 16 pro-inflammatory cytokines using the Canine Cytokine SpikeMix and target mass spectrometry via multiple reaction monitor","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-16T23:17:49.576Z","creation":"2026-07-12T03:11:26.127Z"},"accession":"S-EPMC12949407","cross_references":{"pubmed":["39949047"],"doi":["10.1111/vop.13321"]}}