biostudies-literatureNiyomsri SResearch EnglandWellcome Truste70139https://www.ebi.ac.uk/biostudies/studies/S-EPMC12949456biostudies-literatureUnknown33(4)Approximately 8.8 million people are living with chronic hepatitis C virus (HCV) in Pakistan. We assessed factors related to health-related quality of life (HRQoL) among the general population screened for HCV and calculated the national burden in quality-adjusted life years (QALYs). A cross-sectional study was conducted in community and clinic-based settings in Karachi and Gujranwala. HRQoL was assessed before diagnosis using EQ-5D-3L (Pakistan value set). Propensity score matching (PSM) was used to address socio-economic differences between HCV RNA-positive (viraemic) and HCV-antibody-negative participants. We assessed socio-demographic and HCV-related predictors of HRQoL (Tobit regression) and problems by EQ-5D domain (logistic regression). The HCV transmission model was used to estimatJournal of viral hepatitisThe Impact of Hepatitis C and Socio-Demographic Variables on Health-Related Quality of Life in Pakistan: Cross-Sectional Study.PMC12949456220866/Z/20/ZRE-CL-2023-09Chaudhry AKemos PHasnain ANiaz SWalker JGRamzan AFoster GRChoudhry NAsim MHepFreePak teamAlam EHamid SSSaadullah MChoudhry AArif AQureshi HVickerman PTahir MSHai GSaghir AMetcalfe CKhan TShafqat MNNiyomsri SLim AGfalseThe Impact of Hepatitis C and Socio-Demographic Variables on Health-Related Quality of Life in Pakistan: Cross-Sectional Study.Approximately 8.8 million people are living with chronic hepatitis C virus (HCV) in Pakistan. We assessed factors related to health-related quality of life (HRQoL) among the general population screened for HCV and calculated the national burden in quality-adjusted life years (QALYs). A cross-sectional study was conducted in community and clinic-based settings in Karachi and Gujranwala. HRQoL was assessed before diagnosis using EQ-5D-3L (Pakistan value set). Propensity score matching (PSM) was used to address socio-economic differences between HCV RNA-positive (viraemic) and HCV-antibody-negative participants. We assessed socio-demographic and HCV-related predictors of HRQoL (Tobit regression) and problems by EQ-5D domain (logistic regression). The HCV transmission model was used to estimat2026-01-01T00:00:00Z2026 Apr2026-07-16T23:34:02.371Z2026-07-12T03:11:31.636ZS-EPMC129494564176183510.1111/jvh.70139