biostudies-literatureUnknown40(9)Yoshida HRecently, a novel DNA virus designated SEN virus (SEN-V), which is thought to be related to posttransfusion hepatitis, was discovered. The aim of the present study was to clarify the relationship between SEN-V infection and the development of liver disease. We examined SEN-V from the sera of 21 patients with non-B, non-C hepatocellular carcinoma (HCC) and 13 patients with non-B, non-C chronic liver disease (CLD) without HCC who were admitted to our hospital between 1995 and 1997. Thirty-two patients without liver disease served as controls and were also examined for SEN-V. SEN-V DNA was detected by the nested PCR method after extraction of DNA from serum. SEN-V DNA was detected in 74% (25 of 34) of patients with CLD with or without HCC who were negative for both hepatitis B virus surface aJournal of clinical microbiology3140-5https://www.ebi.ac.uk/biostudies/studies/S-EPMC130791biostudies-literatureWeak association between SEN virus viremia and liver disease.PMC130791Omata MKato NShiina SYoshida HShao RWang YShiratori YfalseWeak association between SEN virus viremia and liver disease.Recently, a novel DNA virus designated SEN virus (SEN-V), which is thought to be related to posttransfusion hepatitis, was discovered. The aim of the present study was to clarify the relationship between SEN-V infection and the development of liver disease. We examined SEN-V from the sera of 21 patients with non-B, non-C hepatocellular carcinoma (HCC) and 13 patients with non-B, non-C chronic liver disease (CLD) without HCC who were admitted to our hospital between 1995 and 1997. Thirty-two patients without liver disease served as controls and were also examined for SEN-V. SEN-V DNA was detected by the nested PCR method after extraction of DNA from serum. SEN-V DNA was detected in 74% (25 of 34) of patients with CLD with or without HCC who were negative for both hepatitis B virus surface a2002-01-01T00:00:00Z2002 Sep2025-04-27T03:48:51.993Z2019-03-27T00:17:20ZS-EPMC1307911220254410.1128/jcm.40.9.3140-3145.200210.1128/JCM.40.9.3140-3145.2002