{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Miller KA"],"funding":["NCRR NIH HHS","NIAID NIH HHS"],"pagination":["2589-99"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC1360202"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["48(7)"],"pubmed_abstract":["Lipopolysaccharides (LPS), otherwise termed \"endotoxins\", are outer membrane constituents of Gram-negative bacteria. Lipopolysaccharides play a key role in the pathogenesis of \"septic shock\", a major cause of mortality in the critically ill patient. Therapeutic options aimed at limiting downstream systemic inflammatory processes by targeting lipopolysaccharide do not exist at the present time. We have defined the pharmacophore necessary for small molecules to specifically bind and neutralize LPS and, using animal models of sepsis, have shown that the sequestration of circulatory LPS by small molecules is a therapeutically viable strategy. In this paper, the interactions of a series of acylated homologated spermine compounds with LPS have been characterized. The optimal acyl chain length fo"],"journal":["Journal of medicinal chemistry"],"pubmed_title":["Lipopolysaccharide sequestrants: structural correlates of activity and toxicity in novel acylhomospermines."],"pmcid":["PMC1360202"],"funding_grant_id":["R01 AI050107","P20 RR015563","1R01 AI50107","R01 AI050107-02","R01 AI050107-01A2"],"pubmed_authors":["Datta A","David SA","Wood SJ","Cromer JR","Miller KA","Suresh Kumar EV"],"additional_accession":[]},"is_claimable":false,"name":"Lipopolysaccharide sequestrants: structural correlates of activity and toxicity in novel acylhomospermines.","description":"Lipopolysaccharides (LPS), otherwise termed \"endotoxins\", are outer membrane constituents of Gram-negative bacteria. Lipopolysaccharides play a key role in the pathogenesis of \"septic shock\", a major cause of mortality in the critically ill patient. Therapeutic options aimed at limiting downstream systemic inflammatory processes by targeting lipopolysaccharide do not exist at the present time. We have defined the pharmacophore necessary for small molecules to specifically bind and neutralize LPS and, using animal models of sepsis, have shown that the sequestration of circulatory LPS by small molecules is a therapeutically viable strategy. In this paper, the interactions of a series of acylated homologated spermine compounds with LPS have been characterized. The optimal acyl chain length fo","dates":{"release":"2005-01-01T00:00:00Z","publication":"2005 Apr","modification":"2025-04-22T01:04:13.609Z","creation":"2019-03-27T01:25:52Z"},"accession":"S-EPMC1360202","cross_references":{"pubmed":["15801849"],"doi":["10.1021/jm049449j"]}}