{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["76(15)"],"submitter":["Williams OM"],"funding":["Wellcome Trust"],"pubmed_abstract":["Human papillomavirus type 11 (HPV-11) infection causes genital warts and recurrent respiratory papillomatosis. While there is compelling evidence that CD4(+) T cells play an important role in immune surveillance of HPV-associated diseases, little is known about human CD4(+) T-cell recognition of HPV-11. We have investigated the CD4(+) T-cell responses of 25 unrelated healthy donors to HPV-11 L1 virus-like particles (VLP). CD4(+) T-cell lines from 21 of 25 donors were established. Cell sorting experiments carried out on cells from six donors demonstrated that the response was located in the CD45RA(low) CD45RO(high) memory T-cell population. To determine the peptide specificity of these responses, epitope selection was analyzed by using 95 15-mer peptides spanning the entire HPV-11 L1 protei"],"journal":["Journal of virology"],"pagination":["7418-29"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC136402"],"repository":["biostudies-literature"],"pubmed_title":["Analysis of CD4(+) T-cell responses to human papillomavirus (HPV) type 11 L1 in healthy adults reveals a high degree of responsiveness and cross-reactivity with other HPV types."],"pmcid":["PMC136402"],"pubmed_authors":["Williams OM","Hart KW","Wang EC","Gelder CM"],"additional_accession":[]},"is_claimable":false,"name":"Analysis of CD4(+) T-cell responses to human papillomavirus (HPV) type 11 L1 in healthy adults reveals a high degree of responsiveness and cross-reactivity with other HPV types.","description":"Human papillomavirus type 11 (HPV-11) infection causes genital warts and recurrent respiratory papillomatosis. While there is compelling evidence that CD4(+) T cells play an important role in immune surveillance of HPV-associated diseases, little is known about human CD4(+) T-cell recognition of HPV-11. We have investigated the CD4(+) T-cell responses of 25 unrelated healthy donors to HPV-11 L1 virus-like particles (VLP). CD4(+) T-cell lines from 21 of 25 donors were established. Cell sorting experiments carried out on cells from six donors demonstrated that the response was located in the CD45RA(low) CD45RO(high) memory T-cell population. To determine the peptide specificity of these responses, epitope selection was analyzed by using 95 15-mer peptides spanning the entire HPV-11 L1 protei","dates":{"release":"2002-01-01T00:00:00Z","publication":"2002 Aug","modification":"2025-05-29T19:23:25.414Z","creation":"2019-03-27T00:17:25Z"},"accession":"S-EPMC136402","cross_references":{"pubmed":["12097554"],"doi":["10.1128/jvi.76.15.7418-7429.2002"]}}