{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lukashevich IS"],"funding":["NCRR NIH HHS"],"pagination":["1727-37"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC140927"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["77(3)"],"pubmed_abstract":["Lymphocytic choriomeningitis virus (LCMV) and Lassa virus can cause hemorrhagic fever and liver disease in primates. The WE strain of LCMV (LCMV-WE) causes a fatal Lassa fever-like disease in rhesus macaques and provides a model for arenavirus pathogenesis in humans. LCMV-WE delivered intravenously or intragastrically to rhesus macaques targets hepatocytes and induces high levels of liver enzymes, interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6R), and soluble tumor necrosis factor receptors (sTNFRI and -II) in plasma during acute infection. Proinflammatory cytokines TNF-alpha and IL-1beta were not detected in plasma of infected animals, but increased plasma gamma interferon was noted in fatally infected animals. Immunohistochemistry of acute liver biopsies revealed that 25 to 40% of nuc"],"journal":["Journal of virology"],"pubmed_title":["Arenavirus-mediated liver pathology: acute lymphocytic choriomeningitis virus infection of rhesus macaques is characterized by high-level interleukin-6 expression and hepatocyte proliferation."],"pmcid":["PMC140927"],"funding_grant_id":["R01-RR13980"],"pubmed_authors":["Djavani M","Lukashevich IS","Yang Y","Zapata JC","Rodas JD","Salvato MS","Tikhonov I"],"additional_accession":[]},"is_claimable":false,"name":"Arenavirus-mediated liver pathology: acute lymphocytic choriomeningitis virus infection of rhesus macaques is characterized by high-level interleukin-6 expression and hepatocyte proliferation.","description":"Lymphocytic choriomeningitis virus (LCMV) and Lassa virus can cause hemorrhagic fever and liver disease in primates. The WE strain of LCMV (LCMV-WE) causes a fatal Lassa fever-like disease in rhesus macaques and provides a model for arenavirus pathogenesis in humans. LCMV-WE delivered intravenously or intragastrically to rhesus macaques targets hepatocytes and induces high levels of liver enzymes, interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6R), and soluble tumor necrosis factor receptors (sTNFRI and -II) in plasma during acute infection. Proinflammatory cytokines TNF-alpha and IL-1beta were not detected in plasma of infected animals, but increased plasma gamma interferon was noted in fatally infected animals. Immunohistochemistry of acute liver biopsies revealed that 25 to 40% of nuc","dates":{"release":"2003-01-01T00:00:00Z","publication":"2003 Feb","modification":"2025-04-04T23:55:02.838Z","creation":"2019-03-27T00:17:30Z"},"accession":"S-EPMC140927","cross_references":{"pubmed":["12525606"],"doi":["10.1128/jvi.77.3.1727-1737.2003"]}}