{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tagoh H"],"funding":["Medical Research Council"],"pagination":["1070-80"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC1409732"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(5)"],"pubmed_abstract":["The transcription factor Pax5 (BSAP) is required for the expression of a B-cell-specific genetic program and for B-cell differentiation, and also to suppress genes of alternative lineages. The molecular mechanism by which repression of myeloid genes occurs during early B-lineage restriction is unknown and in this study we addressed this question. One of the genes repressed by Pax5 in B cells is the colony-stimulating factor receptor 1 gene (csf1r or c-fms). We examined the changes in chromatin caused by Pax5 activity, and we show that Pax5 is directly recruited to c-fms resulting in the rapid loss of RNA polymerase II binding, followed by loss of transcription factor binding and DNaseI hypersensitivity at all cis-regulatory elements. We also show that Pax5 targets the basal transcription m"],"journal":["The EMBO journal"],"pubmed_title":["The mechanism of repression of the myeloid-specific c-fms gene by Pax5 during B lineage restriction."],"pmcid":["PMC1409732"],"funding_grant_id":["MC_U105161083"],"pubmed_authors":["Bonifer C","Warren AJ","Ingram R","Clarke D","Busslinger M","Salvagiotto G","Tagoh H","Wilson N"],"additional_accession":[]},"is_claimable":false,"name":"The mechanism of repression of the myeloid-specific c-fms gene by Pax5 during B lineage restriction.","description":"The transcription factor Pax5 (BSAP) is required for the expression of a B-cell-specific genetic program and for B-cell differentiation, and also to suppress genes of alternative lineages. The molecular mechanism by which repression of myeloid genes occurs during early B-lineage restriction is unknown and in this study we addressed this question. One of the genes repressed by Pax5 in B cells is the colony-stimulating factor receptor 1 gene (csf1r or c-fms). We examined the changes in chromatin caused by Pax5 activity, and we show that Pax5 is directly recruited to c-fms resulting in the rapid loss of RNA polymerase II binding, followed by loss of transcription factor binding and DNaseI hypersensitivity at all cis-regulatory elements. We also show that Pax5 targets the basal transcription m","dates":{"release":"2006-01-01T00:00:00Z","publication":"2006 Mar","modification":"2026-05-02T09:06:13.126Z","creation":"2026-04-07T17:46:50.647Z"},"accession":"S-EPMC1409732","cross_references":{"pubmed":["16482219"],"doi":["10.1038/sj.emboj.7600997"]}}