biostudies-literatureDeCarlo AANIDCR NIH HHS562-6https://www.ebi.ac.uk/biostudies/studies/S-EPMC143394biostudies-literatureUnknown71(1)In a rat periodontitis model, preinoculation with the Porphyromonas gingivalis HA2 binding domain for hemoglobin provided protection from disease. Protection was associated with induced anti-HA2 immunoglobulin G (IgG) humoral antibodies. The IgG subclass ratios suggested that relatively lower Th2/Th1-driven responses were directly associated with protection when rHA2 was administered in saline.Infection and immunityFeasibility of an HA2 domain-based periodontitis vaccine.PMC143394R43DE14013-01DeCarlo AAHuang YCollyer CALangley DBKatz JfalseFeasibility of an HA2 domain-based periodontitis vaccine.In a rat periodontitis model, preinoculation with the Porphyromonas gingivalis HA2 binding domain for hemoglobin provided protection from disease. Protection was associated with induced anti-HA2 immunoglobulin G (IgG) humoral antibodies. The IgG subclass ratios suggested that relatively lower Th2/Th1-driven responses were directly associated with protection when rHA2 was administered in saline.2003-01-01T00:00:00Z2003 Jan2025-04-21T15:30:03.894Z2019-03-27T00:17:33ZS-EPMC1433941249621210.1128/IAI.71.1.562-566.200310.1128/iai.71.1.562-566.2003