{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Laouar A"],"funding":["NIAID NIH HHS"],"pagination":["698-706"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC1444945"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(7)"],"pubmed_abstract":["One unresolved issue in gut immunity is how mucosal T lymphocytes are activated and which antigen-presenting cell (APC) is critical for the regulation of this process. We have identified a unique population of APCs that is exclusively localized in the lamina propria. These APCs constitutively expressed the costimulatory molecule CD70 and had antigen-presenting functions. After oral infection of mice with Listeria monocytogenes, proliferation and differentiation of antigen-specific T cells occurred in the gut mucosa in situ and blockade of CD70 costimulation abrogated the mucosal T cell proliferation and effector functions. Thus, a potent CD70-dependent stimulation via specialized tissue-specific APCs is required for the proliferation and differentiation of gut mucosal T cells after oral in"],"journal":["Nature immunology"],"pubmed_title":["CD70+ antigen-presenting cells control the proliferation and differentiation of T cells in the intestinal mucosa."],"pmcid":["PMC1444945"],"funding_grant_id":["AI46566","R21 AI046566","R01 AI046566"],"pubmed_authors":["Chaplin D","Zhinan X","Laouar A","Vargas D","Manjunath N","van Lier RA","Haridas V"],"additional_accession":[]},"is_claimable":false,"name":"CD70+ antigen-presenting cells control the proliferation and differentiation of T cells in the intestinal mucosa.","description":"One unresolved issue in gut immunity is how mucosal T lymphocytes are activated and which antigen-presenting cell (APC) is critical for the regulation of this process. We have identified a unique population of APCs that is exclusively localized in the lamina propria. These APCs constitutively expressed the costimulatory molecule CD70 and had antigen-presenting functions. After oral infection of mice with Listeria monocytogenes, proliferation and differentiation of antigen-specific T cells occurred in the gut mucosa in situ and blockade of CD70 costimulation abrogated the mucosal T cell proliferation and effector functions. Thus, a potent CD70-dependent stimulation via specialized tissue-specific APCs is required for the proliferation and differentiation of gut mucosal T cells after oral in","dates":{"release":"2005-01-01T00:00:00Z","publication":"2005 Jul","modification":"2025-04-27T03:55:12.879Z","creation":"2019-03-27T01:26:16Z"},"accession":"S-EPMC1444945","cross_references":{"pubmed":["15937486"],"doi":["10.1038/ni1212"]}}