biostudies-literatureUnknown7Song J<h4>Background</h4>The majority of peptide bonds in proteins are found to occur in the trans conformation. However, for proline residues, a considerable fraction of Prolyl peptide bonds adopt the cis form. Proline cis/trans isomerization is known to play a critical role in protein folding, splicing, cell signaling and transmembrane active transport. Accurate prediction of proline cis/trans isomerization in proteins would have many important applications towards the understanding of protein structure and function.<h4>Results</h4>In this paper, we propose a new approach to predict the proline cis/trans isomerization in proteins using support vector machine (SVM). The preliminary results indicated that using Radial Basis Function (RBF) kernels could lead to better prediction performance than BMC bioinformatics124https://www.ebi.ac.uk/biostudies/studies/S-EPMC1450308biostudies-literaturePrediction of cis/trans isomerization in proteins using PSI-BLAST profiles and secondary structure information.PMC1450308Burrage KHuber TSong JYuan ZfalsePrediction of cis/trans isomerization in proteins using PSI-BLAST profiles and secondary structure information.<h4>Background</h4>The majority of peptide bonds in proteins are found to occur in the trans conformation. However, for proline residues, a considerable fraction of Prolyl peptide bonds adopt the cis form. Proline cis/trans isomerization is known to play a critical role in protein folding, splicing, cell signaling and transmembrane active transport. Accurate prediction of proline cis/trans isomerization in proteins would have many important applications towards the understanding of protein structure and function.<h4>Results</h4>In this paper, we propose a new approach to predict the proline cis/trans isomerization in proteins using support vector machine (SVM). The preliminary results indicated that using Radial Basis Function (RBF) kernels could lead to better prediction performance than 2006-01-01T00:00:00Z2006 Mar2025-04-19T15:47:50.118Z2019-03-27T01:26:22ZS-EPMC14503081652695610.1186/1471-2105-7-124