biostudies-literatureUnknown103(14)Bootsma MCControl of nosocomial transmission of methicillin-resistant Staphylococcus aureus (MRSA) has been unsuccessful in most countries. Yet, some countries have maintained low endemic levels by implementing nationwide MRSA-specific infection control measures, such as "search & destroy" (S&D). These strategies, however, are not based on well designed studies, and their use in countries with high levels of endemicity is controversial. We present a stochastic three-hospital model and an analytical one-hospital model to quantify the effectiveness of different infection control measures and to predict the effects of rapid diagnostic testing (RDT) on isolation needs. Isolation of MRSA carriers identified by clinical cultures is insufficient to control MRSA. However, combined with proactive search (of Proceedings of the National Academy of Sciences of the United States of America5620-5https://www.ebi.ac.uk/biostudies/studies/S-EPMC1459403biostudies-literatureControlling methicillin-resistant Staphylococcus aureus: quantifying the effects of interventions and rapid diagnostic testing.PMC1459403Diekmann OBonten MJBootsma MCfalseControlling methicillin-resistant Staphylococcus aureus: quantifying the effects of interventions and rapid diagnostic testing.Control of nosocomial transmission of methicillin-resistant Staphylococcus aureus (MRSA) has been unsuccessful in most countries. Yet, some countries have maintained low endemic levels by implementing nationwide MRSA-specific infection control measures, such as "search & destroy" (S&D). These strategies, however, are not based on well designed studies, and their use in countries with high levels of endemicity is controversial. We present a stochastic three-hospital model and an analytical one-hospital model to quantify the effectiveness of different infection control measures and to predict the effects of rapid diagnostic testing (RDT) on isolation needs. Isolation of MRSA carriers identified by clinical cultures is insufficient to control MRSA. However, combined with proactive search (of 2006-01-01T00:00:00Z2006 Apr2025-04-20T00:24:43.64Z2019-03-27T01:26:26ZS-EPMC14594031656521910.1073/pnas.0510077103