{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7"],"submitter":["Lee JA"],"pubmed_abstract":["<h4>Background</h4>Activation of naïve B lymphocytes by extracellular ligands, e.g. antigen, lipopolysaccharide (LPS) and CD40 ligand, induces a combination of common and ligand-specific phenotypic changes through complex signal transduction pathways. For example, although all three of these ligands induce proliferation, only stimulation through the B cell antigen receptor (BCR) induces apoptosis in resting splenic B cells. In order to define the common and unique biological responses to ligand stimulation, we compared the gene expression changes induced in normal primary B cells by a panel of ligands using cDNA microarrays and a statistical approach, CLASSIFI (Cluster Assignment for Biological Inference), which identifies significant co-clustering of genes with similar Gene Ontology annot"],"journal":["BMC bioinformatics"],"pagination":["237"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC1479375"],"repository":["biostudies-literature"],"pubmed_title":["Components of the antigen processing and presentation pathway revealed by gene expression microarray analysis following B cell antigen receptor (BCR) stimulation."],"pmcid":["PMC1479375"],"pubmed_authors":["Choi S","Scheuermann RH","Mock D","Alliance for Cellular Signaling","Hsueh RC","Rab EL","Saunders B","Lee JA","Sinkovits RS","Cai J","Yang P","Subramaniam S"],"additional_accession":[]},"is_claimable":false,"name":"Components of the antigen processing and presentation pathway revealed by gene expression microarray analysis following B cell antigen receptor (BCR) stimulation.","description":"<h4>Background</h4>Activation of naïve B lymphocytes by extracellular ligands, e.g. antigen, lipopolysaccharide (LPS) and CD40 ligand, induces a combination of common and ligand-specific phenotypic changes through complex signal transduction pathways. For example, although all three of these ligands induce proliferation, only stimulation through the B cell antigen receptor (BCR) induces apoptosis in resting splenic B cells. In order to define the common and unique biological responses to ligand stimulation, we compared the gene expression changes induced in normal primary B cells by a panel of ligands using cDNA microarrays and a statistical approach, CLASSIFI (Cluster Assignment for Biological Inference), which identifies significant co-clustering of genes with similar Gene Ontology annot","dates":{"release":"2006-01-01T00:00:00Z","publication":"2006 May","modification":"2026-04-07T20:47:16.025Z","creation":"2019-03-27T01:45:29Z"},"accession":"S-EPMC1479375","cross_references":{"pubmed":["16670020"],"doi":["10.1186/1471-2105-7-237"]}}