{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["26(11)"],"submitter":["Mar L"],"pubmed_abstract":["Holoprosencephaly (HPE) is the most common structural anomaly of the human brain, resulting from incomplete cleavage of the developing forebrain during embryogenesis. Haploinsufficient mutations in the TG-interacting factor (TGIF) gene were previously identified in a subset of HPE families and sporadic patients, and this gene is located within a region of chromosome 18 that is associated with nonrandom chromosomal aberrations in HPE patients. TGIF is a three-amino-acid loop extension (TALE) homeodomain-containing transcription factor that functions both as a corepressor of the transforming growth factor beta (TGF-beta) pathway and as a competitor of the retinoic acid pathway. Here we describe mice deficient in Tgif that exhibited laterality defects and growth retardation and developed kink"],"journal":["Molecular and cellular biology"],"pagination":["4302-10"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC1489080"],"repository":["biostudies-literature"],"pubmed_title":["Embryonic fibroblasts from mice lacking Tgif were defective in cell cycling."],"pmcid":["PMC1489080"],"pubmed_authors":["Mar L","Hoodless PA"],"additional_accession":[]},"is_claimable":false,"name":"Embryonic fibroblasts from mice lacking Tgif were defective in cell cycling.","description":"Holoprosencephaly (HPE) is the most common structural anomaly of the human brain, resulting from incomplete cleavage of the developing forebrain during embryogenesis. Haploinsufficient mutations in the TG-interacting factor (TGIF) gene were previously identified in a subset of HPE families and sporadic patients, and this gene is located within a region of chromosome 18 that is associated with nonrandom chromosomal aberrations in HPE patients. TGIF is a three-amino-acid loop extension (TALE) homeodomain-containing transcription factor that functions both as a corepressor of the transforming growth factor beta (TGF-beta) pathway and as a competitor of the retinoic acid pathway. Here we describe mice deficient in Tgif that exhibited laterality defects and growth retardation and developed kink","dates":{"release":"2006-01-01T00:00:00Z","publication":"2006 Jun","modification":"2025-04-19T15:47:31.065Z","creation":"2019-03-27T01:45:33Z"},"accession":"S-EPMC1489080","cross_references":{"pubmed":["16705179"],"doi":["10.1128/mcb.02156-05","10.1128/MCB.02156-05"]}}