biostudies-literatureUnknown26(11)Mar LHoloprosencephaly (HPE) is the most common structural anomaly of the human brain, resulting from incomplete cleavage of the developing forebrain during embryogenesis. Haploinsufficient mutations in the TG-interacting factor (TGIF) gene were previously identified in a subset of HPE families and sporadic patients, and this gene is located within a region of chromosome 18 that is associated with nonrandom chromosomal aberrations in HPE patients. TGIF is a three-amino-acid loop extension (TALE) homeodomain-containing transcription factor that functions both as a corepressor of the transforming growth factor beta (TGF-beta) pathway and as a competitor of the retinoic acid pathway. Here we describe mice deficient in Tgif that exhibited laterality defects and growth retardation and developed kinkMolecular and cellular biology4302-10https://www.ebi.ac.uk/biostudies/studies/S-EPMC1489080biostudies-literatureEmbryonic fibroblasts from mice lacking Tgif were defective in cell cycling.PMC1489080Mar LHoodless PAfalseEmbryonic fibroblasts from mice lacking Tgif were defective in cell cycling.Holoprosencephaly (HPE) is the most common structural anomaly of the human brain, resulting from incomplete cleavage of the developing forebrain during embryogenesis. Haploinsufficient mutations in the TG-interacting factor (TGIF) gene were previously identified in a subset of HPE families and sporadic patients, and this gene is located within a region of chromosome 18 that is associated with nonrandom chromosomal aberrations in HPE patients. TGIF is a three-amino-acid loop extension (TALE) homeodomain-containing transcription factor that functions both as a corepressor of the transforming growth factor beta (TGF-beta) pathway and as a competitor of the retinoic acid pathway. Here we describe mice deficient in Tgif that exhibited laterality defects and growth retardation and developed kink2006-01-01T00:00:00Z2006 Jun2025-04-19T15:47:31.065Z2019-03-27T01:45:33ZS-EPMC14890801670517910.1128/mcb.02156-0510.1128/MCB.02156-05