{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Boyle JP"],"funding":["Intramural NIH HHS","NIAID NIH HHS","Wellcome Trust"],"pagination":["10514-10519"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC1502489"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["103(27)"],"pubmed_abstract":["Toxoplasma gondii, an obligate intracellular protozoan of the phylum Apicomplexa, is estimated to infect over a billion people worldwide as well as a great many other mammalian and avian hosts. Despite this ubiquity, the vast majority of human infections in Europe and North America are thought to be due to only three genotypes. Using a genome-wide analysis of single-nucleotide polymorphisms, we have constructed a genealogy for these three lines. The data indicate that types I and III are second- and first-generation offspring, respectively, of a cross between a type II strain and one of two ancestral strains. An extant T. gondii strain (P89) appears to be the modern descendant of the non-type II parent of type III, making the full genealogy of the type III clonotype known. The simplicity o"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Just one cross appears capable of dramatically altering the population biology of a eukaryotic pathogen like Toxoplasma gondii."],"pmcid":["PMC1502489"],"funding_grant_id":["R01 AI021423","AI045806","R21 AI045806","F32 AI060306","R37 AI021423","Z01 AI005093","R01 AI041014","AI21423","AI41014","R01 AI045806","R01 AI036629","AI05093","F32AI60306"],"pubmed_authors":["Paulsen I","Rajasekar B","Berriman M","Sibley LD","Saeij JPJ","Roos DS","Boothroyd JC","Boyle JP","Ajioka JW","White MW"],"additional_accession":[]},"is_claimable":false,"name":"Just one cross appears capable of dramatically altering the population biology of a eukaryotic pathogen like Toxoplasma gondii.","description":"Toxoplasma gondii, an obligate intracellular protozoan of the phylum Apicomplexa, is estimated to infect over a billion people worldwide as well as a great many other mammalian and avian hosts. Despite this ubiquity, the vast majority of human infections in Europe and North America are thought to be due to only three genotypes. Using a genome-wide analysis of single-nucleotide polymorphisms, we have constructed a genealogy for these three lines. The data indicate that types I and III are second- and first-generation offspring, respectively, of a cross between a type II strain and one of two ancestral strains. An extant T. gondii strain (P89) appears to be the modern descendant of the non-type II parent of type III, making the full genealogy of the type III clonotype known. The simplicity o","dates":{"release":"2006-01-01T00:00:00Z","publication":"2006 Jul","modification":"2026-04-29T20:47:53.19Z","creation":"2019-03-27T01:45:37Z"},"accession":"S-EPMC1502489","cross_references":{"pubmed":["16801557"],"doi":["10.1073/pnas.0510319103"]}}