{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["3(1)"],"submitter":["Kato T"],"pubmed_abstract":["Activation of the Wnt-signaling pathway is known to play a crucial role in carcinogenesis of various human organs including the colon, liver, prostate, and endometrium. To investigate the mechanisms underlying hepatocellular carcinogenesis, we attempted to identify genes regulated by beta-catenin/Tcf complex in a human hepatoma cell line, HepG2, in which an activated form of beta-catenin is expressed. By means of cDNA microarray, we isolated a novel human gene, termed MARKL1 (MAP/microtubule affinity-regulating kinase-like 1), whose expression was downregulated in response to decreased Tcf/LEF1 activity. The transcript expressed in liver consisted of 3529 nucleotides that contained an open reading frame of 2256 nucleotides, encoding 752 amino acids homologous to human MARK3 (MAP/microtubul"],"journal":["Neoplasia (New York, N.Y.)"],"pagination":["4-9"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC1505019"],"repository":["biostudies-literature"],"pubmed_title":["Isolation of a novel human gene, MARKL1, homologous to MARK3 and its involvement in hepatocellular carcinogenesis."],"pmcid":["PMC1505019"],"pubmed_authors":["Satoh S","Kihara C","Furukawa Y","Okabe H","Ono K","Tanaka T","Nakamura Y","Yamaoka Y","Kitahara O","Tsunoda T","Kato T"],"additional_accession":[]},"is_claimable":false,"name":"Isolation of a novel human gene, MARKL1, homologous to MARK3 and its involvement in hepatocellular carcinogenesis.","description":"Activation of the Wnt-signaling pathway is known to play a crucial role in carcinogenesis of various human organs including the colon, liver, prostate, and endometrium. To investigate the mechanisms underlying hepatocellular carcinogenesis, we attempted to identify genes regulated by beta-catenin/Tcf complex in a human hepatoma cell line, HepG2, in which an activated form of beta-catenin is expressed. By means of cDNA microarray, we isolated a novel human gene, termed MARKL1 (MAP/microtubule affinity-regulating kinase-like 1), whose expression was downregulated in response to decreased Tcf/LEF1 activity. The transcript expressed in liver consisted of 3529 nucleotides that contained an open reading frame of 2256 nucleotides, encoding 752 amino acids homologous to human MARK3 (MAP/microtubul","dates":{"release":"2001-01-01T00:00:00Z","publication":"2001 Jan-Feb","modification":"2025-04-21T16:01:54.244Z","creation":"2019-03-27T01:45:37Z"},"accession":"S-EPMC1505019","cross_references":{"pubmed":["11326310"],"doi":["10.1038/sj.neo.7900132"]}}