biostudies-literatureUnknown333(7565)Ho KM<h4>Objective</h4>To investigate the potential beneficial and adverse effects of frusemide to prevent or treat acute renal failure in adults.<h4>Design</h4>Meta-analysis of randomised controlled trials.<h4>Data sources</h4>Cochrane controlled trials register (2005 issue 4), Embase, and Medline (1966 to 1 February 2006), without language restrictions.<h4>Review methods</h4>Two reviewers checked the quality of the studies and independently extracted data.<h4>Results</h4>Nine randomised controlled trials totalling 849 patients with or at risk of acute renal failure were included. Outcome measures not significantly different after frusemide treatment were in-hospital mortality (relative risk 1.11, 95% confidence interval 0.92 to 1.33), risk for requiring renal replacement therapy or dialysis (BMJ (Clinical research ed.)420https://www.ebi.ac.uk/biostudies/studies/S-EPMC1553510biostudies-literatureMeta-analysis of frusemide to prevent or treat acute renal failure.PMC1553510Ho KMSheridan DJfalseMeta-analysis of frusemide to prevent or treat acute renal failure.<h4>Objective</h4>To investigate the potential beneficial and adverse effects of frusemide to prevent or treat acute renal failure in adults.<h4>Design</h4>Meta-analysis of randomised controlled trials.<h4>Data sources</h4>Cochrane controlled trials register (2005 issue 4), Embase, and Medline (1966 to 1 February 2006), without language restrictions.<h4>Review methods</h4>Two reviewers checked the quality of the studies and independently extracted data.<h4>Results</h4>Nine randomised controlled trials totalling 849 patients with or at risk of acute renal failure were included. Outcome measures not significantly different after frusemide treatment were in-hospital mortality (relative risk 1.11, 95% confidence interval 0.92 to 1.33), risk for requiring renal replacement therapy or dialysis (2006-01-01T00:00:00Z2006 Aug2025-04-19T13:09:24.457Z2019-03-27T01:45:47ZS-EPMC15535101686125610.1136/bmj.38902.605347.7C10.1136/bmj.38902.605347.7c