{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["272(1572)"],"submitter":["van Boven M"],"pubmed_abstract":["Mass vaccination campaigns have drastically reduced the burden of infectious diseases. Unfortunately, in recent years several infectious diseases have re-emerged. Pertussis poses a well-known example. Inspired by pertussis, we study, by means of an epidemic model, the population and evolutionary dynamics of a pathogen population under the pressure of vaccination. A distinction is made between infection in immunologically naive individuals (primary infection) and infection in individuals whose immune system has been primed by vaccination or infection (secondary infection). The results show that (i) vaccination with an imperfect vaccine may not succeed in reducing the infection pressure if the transmissibility of secondary infections is higher than that of primary infections; (ii) pathogen s"],"journal":["Proceedings. Biological sciences"],"pagination":["1617-24"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC1559845"],"repository":["biostudies-literature"],"pubmed_title":["Pathogen adaptation under imperfect vaccination: implications for pertussis."],"pmcid":["PMC1559845"],"pubmed_authors":["Schellekens JF","Kretzschmar M","Mooi FR","van Boven M","de Melker HE"],"additional_accession":[]},"is_claimable":false,"name":"Pathogen adaptation under imperfect vaccination: implications for pertussis.","description":"Mass vaccination campaigns have drastically reduced the burden of infectious diseases. Unfortunately, in recent years several infectious diseases have re-emerged. Pertussis poses a well-known example. Inspired by pertussis, we study, by means of an epidemic model, the population and evolutionary dynamics of a pathogen population under the pressure of vaccination. A distinction is made between infection in immunologically naive individuals (primary infection) and infection in individuals whose immune system has been primed by vaccination or infection (secondary infection). The results show that (i) vaccination with an imperfect vaccine may not succeed in reducing the infection pressure if the transmissibility of secondary infections is higher than that of primary infections; (ii) pathogen s","dates":{"release":"2005-01-01T00:00:00Z","publication":"2005 Aug","modification":"2025-04-19T07:24:11.35Z","creation":"2019-03-27T01:45:50Z"},"accession":"S-EPMC1559845","cross_references":{"pubmed":["16048777"],"doi":["10.1098/rspb.2005.3108"]}}