{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2"],"submitter":["Baysal BE"],"pubmed_abstract":["<h4>Background</h4>A mannosyltransferase gene (ALG9, DIBD1) at chromosome band 11q23 was previously identified to be disrupted by a balanced chromosomal translocation t(9;11)(p24;q23) co-segregating with bipolar affective disorder in a small family. Inborn ALG9 deficiency (congenital disorders of glycosylation type IL) is associated with progressive microcephaly, seizures, developmental delay, and hepatomegaly. It is unknown whether common variations of ALG9 predispose to bipolar affective disorder.<h4>Methods</h4>We tested five polymorphic markers spanning ALG9 (three intragenic and one upstream microsatellite repeats and one common missense variation, V289I (rs10502151) for their association with bipolar I disorder in two pedigree series. The NIMH (National Institute of Mental Health) pe"],"journal":["Behavioral and brain functions : BBF"],"pagination":["25"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC1569366"],"repository":["biostudies-literature"],"pubmed_title":["Common variations in ALG9 are not associated with bipolar I disorder: a family-based study."],"pmcid":["PMC1569366"],"pubmed_authors":["Nimgaonkar VL","Baysal BE","Bacanu SA","Detera-Wadleigh S","Willett-Brozick JE"],"additional_accession":[]},"is_claimable":false,"name":"Common variations in ALG9 are not associated with bipolar I disorder: a family-based study.","description":"<h4>Background</h4>A mannosyltransferase gene (ALG9, DIBD1) at chromosome band 11q23 was previously identified to be disrupted by a balanced chromosomal translocation t(9;11)(p24;q23) co-segregating with bipolar affective disorder in a small family. Inborn ALG9 deficiency (congenital disorders of glycosylation type IL) is associated with progressive microcephaly, seizures, developmental delay, and hepatomegaly. It is unknown whether common variations of ALG9 predispose to bipolar affective disorder.<h4>Methods</h4>We tested five polymorphic markers spanning ALG9 (three intragenic and one upstream microsatellite repeats and one common missense variation, V289I (rs10502151) for their association with bipolar I disorder in two pedigree series. The NIMH (National Institute of Mental Health) pe","dates":{"release":"2006-01-01T00:00:00Z","publication":"2006 Jul","modification":"2026-04-07T15:52:05.047Z","creation":"2019-03-27T01:45:56Z"},"accession":"S-EPMC1569366","cross_references":{"pubmed":["16859551"],"doi":["10.1186/1744-9081-2-25"]}}