{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["167(1)"],"submitter":["Gebhardt C"],"pubmed_abstract":["Malignant transformation of mouse skin by tumor promoters and chemical carcinogens, such as the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), is a multistage process leading to the formation of squamous cell carcinomas. It has been shown that mice lacking the AP-1 family member c-Fos exhibit an impaired transition from benign to malignant skin tumors. Here, we demonstrate enhanced expression of the small Ras-related GTPase Rab11a after short-term TPA treatment of mouse back skin. Expression of Rab11a in vivo and in vitro critically depended on c-Fos, because TPA application to the back skin of c-Fos-deficient mice and to mouse embryonic fibroblasts did not induce Rab11a mRNA or protein expression. Moreover, dexamethasone, which is a potent inhibitor of AP-1-mediated transactiva"],"journal":["The American journal of pathology"],"pagination":["243-53"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC1603444"],"repository":["biostudies-literature"],"pubmed_title":["c-Fos-dependent induction of the small ras-related GTPase Rab11a in skin carcinogenesis."],"pmcid":["PMC1603444"],"pubmed_authors":["Richter KH","Angel P","Hess J","Breitenbach U","Furstenberger G","Mauch C","Gebhardt C"],"additional_accession":[]},"is_claimable":false,"name":"c-Fos-dependent induction of the small ras-related GTPase Rab11a in skin carcinogenesis.","description":"Malignant transformation of mouse skin by tumor promoters and chemical carcinogens, such as the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), is a multistage process leading to the formation of squamous cell carcinomas. It has been shown that mice lacking the AP-1 family member c-Fos exhibit an impaired transition from benign to malignant skin tumors. Here, we demonstrate enhanced expression of the small Ras-related GTPase Rab11a after short-term TPA treatment of mouse back skin. Expression of Rab11a in vivo and in vitro critically depended on c-Fos, because TPA application to the back skin of c-Fos-deficient mice and to mouse embryonic fibroblasts did not induce Rab11a mRNA or protein expression. Moreover, dexamethasone, which is a potent inhibitor of AP-1-mediated transactiva","dates":{"release":"2005-01-01T00:00:00Z","publication":"2005 Jul","modification":"2026-07-15T03:58:10.958Z","creation":"2019-03-27T01:46:05Z"},"accession":"S-EPMC1603444","cross_references":{"pubmed":["15972968"],"doi":["10.1016/S0002-9440(10)62969-0","10.1016/s0002-9440(10)62969-0"]}}