{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Larsson O"],"funding":["NIAID NIH HHS","NHLBI NIH HHS"],"pagination":["4375-86"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC1636353"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["34(16)"],"pubmed_abstract":["Aberrant activation of the translation initiation machinery is a common property of malignant cells, and is essential for breast carcinoma cells to manifest a malignant phenotype. How does sustained activation of the rate limiting step in protein synthesis so fundamentally alter a cell? In this report, we test the post transcriptional operon theory as a possible mechanism, employing a model system in which apoptosis resistance is conferred on NIH 3T3 cells by ectopic expression of eIF4E. We show (i) there is a set of 255 transcripts that manifest an increase in translational efficiency during eIF4E-mediated escape from apoptosis; (ii) there is a novel prototype 55 nt RNA consensus hairpin structure that is overrepresented in the 5'-untranslated region of translationally activated transcrip"],"journal":["Nucleic acids research"],"pubmed_title":["Apoptosis resistance downstream of eIF4E: posttranscriptional activation of an anti-apoptotic transcript carrying a consensus hairpin structure."],"pmcid":["PMC1636353"],"funding_grant_id":["HL073719","T32 HL07741","P50 HL50152","K08 HL074058","P01 AI050162","R01 HL076779","HL076779","T32 HL007741","1K08-HL074058-01","R01 HL073719","P01 AI50162"],"pubmed_authors":["Polunovsky VA","Peterson M","Larsson O","Li S","Bitterman PB","Liang Z","Reilly CS","Dahlgren C","Perlman DM","Fan D","Wahlestedt C"],"additional_accession":[]},"is_claimable":false,"name":"Apoptosis resistance downstream of eIF4E: posttranscriptional activation of an anti-apoptotic transcript carrying a consensus hairpin structure.","description":"Aberrant activation of the translation initiation machinery is a common property of malignant cells, and is essential for breast carcinoma cells to manifest a malignant phenotype. How does sustained activation of the rate limiting step in protein synthesis so fundamentally alter a cell? In this report, we test the post transcriptional operon theory as a possible mechanism, employing a model system in which apoptosis resistance is conferred on NIH 3T3 cells by ectopic expression of eIF4E. We show (i) there is a set of 255 transcripts that manifest an increase in translational efficiency during eIF4E-mediated escape from apoptosis; (ii) there is a novel prototype 55 nt RNA consensus hairpin structure that is overrepresented in the 5'-untranslated region of translationally activated transcrip","dates":{"release":"2006-01-01T00:00:00Z","publication":"2006","modification":"2026-05-02T19:44:40.792Z","creation":"2019-03-27T01:46:14Z"},"accession":"S-EPMC1636353","cross_references":{"pubmed":["16936314"],"doi":["10.1093/nar/gkl558"]}}