{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["41(7)"],"submitter":["Nicastri E"],"pubmed_abstract":["Whether highly active antiretroviral therapy (HAART) should be modified in patients with persistent increases in CD4(+) T cells despite detectable viral loads is an unresolved question. Forty-three heavily pretreated human immunodeficiency virus (HIV)-infected patients with virologic failure during HAART were studied before a change of therapy guided by genotypic analysis and during follow-up. Patients with an increase in CD4(+) cell count (>100 cells/ml) over pre-HAART values were considered to be discordant patients (20 individuals), whereas patients with a lower increase or no increase in CD4(+) cell count were considered failing patients (23 individuals). Based on univariate analysis, a high CD4(+) cell count before antiretroviral treatment, homosexual behavior as a risk factor for HIV"],"journal":["Journal of clinical microbiology"],"pagination":["3007-12"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC165358"],"repository":["biostudies-literature"],"pubmed_title":["High prevalence of M184 mutation among patients with viroimmunologic discordant responses to highly active antiretroviral therapy and outcomes after change of therapy guided by genotypic analysis."],"pmcid":["PMC165358"],"pubmed_authors":["Montano M","Vullo V","Concia E","d'Ettorre G","Sarmati L","Gatti F","Nicastri E","Uccella I","Vella S","Palmisano L","Galluzzo C","Parisi SG","Amici R","Andreoni M"],"additional_accession":[]},"is_claimable":false,"name":"High prevalence of M184 mutation among patients with viroimmunologic discordant responses to highly active antiretroviral therapy and outcomes after change of therapy guided by genotypic analysis.","description":"Whether highly active antiretroviral therapy (HAART) should be modified in patients with persistent increases in CD4(+) T cells despite detectable viral loads is an unresolved question. Forty-three heavily pretreated human immunodeficiency virus (HIV)-infected patients with virologic failure during HAART were studied before a change of therapy guided by genotypic analysis and during follow-up. Patients with an increase in CD4(+) cell count (>100 cells/ml) over pre-HAART values were considered to be discordant patients (20 individuals), whereas patients with a lower increase or no increase in CD4(+) cell count were considered failing patients (23 individuals). Based on univariate analysis, a high CD4(+) cell count before antiretroviral treatment, homosexual behavior as a risk factor for HIV","dates":{"release":"2003-01-01T00:00:00Z","publication":"2003 Jul","modification":"2025-04-26T15:56:25.869Z","creation":"2019-03-27T00:35:20Z"},"accession":"S-EPMC165358","cross_references":{"pubmed":["12843034"],"doi":["10.1128/jcm.41.7.3007-3012.2003","10.1128/JCM.41.7.3007-3012.2003"]}}