{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Naghavi MH"],"funding":["NCI NIH HHS","NIGMS NIH HHS"],"pagination":["41-52"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC1782362"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(1)"],"pubmed_abstract":["In a functional screen of mammalian complementary DNA libraries, we identified moesin as a novel gene whose overexpression blocks infection by murine leukemia viruses and human immunodeficiency virus type 1 in human and rodent lines, before the initiation of reverse transcription. Knockdown of moesin by RNA interference resulted in enhanced infection, suggesting that even the endogenous basal levels of moesin in rat fibroblasts are sufficient to limit virus infection. Moesin acts as a crosslinker between plasma membrane and actin filaments, as well as a signal transducer in responses involving cytoskeletal remodeling. Moesin overexpression was found to downregulate the formation of stable microtubules, whereas knockdown of moesin increased stable microtubule formation. A virus-resistant mu"],"journal":["The EMBO journal"],"pubmed_title":["Moesin regulates stable microtubule formation and limits retroviral infection in cultured cells."],"pmcid":["PMC1782362"],"funding_grant_id":["R37 CA030488","R01 CA030488","R01 GM068595","CA30488","R37CA30488","GM068595"],"pubmed_authors":["Valente S","Wen Y","de Los Santos K","Hatziioannou T","Mott C","Gundersen GG","Goff SP","Naghavi MH"],"additional_accession":[]},"is_claimable":false,"name":"Moesin regulates stable microtubule formation and limits retroviral infection in cultured cells.","description":"In a functional screen of mammalian complementary DNA libraries, we identified moesin as a novel gene whose overexpression blocks infection by murine leukemia viruses and human immunodeficiency virus type 1 in human and rodent lines, before the initiation of reverse transcription. Knockdown of moesin by RNA interference resulted in enhanced infection, suggesting that even the endogenous basal levels of moesin in rat fibroblasts are sufficient to limit virus infection. Moesin acts as a crosslinker between plasma membrane and actin filaments, as well as a signal transducer in responses involving cytoskeletal remodeling. Moesin overexpression was found to downregulate the formation of stable microtubules, whereas knockdown of moesin increased stable microtubule formation. A virus-resistant mu","dates":{"release":"2007-01-01T00:00:00Z","publication":"2007 Jan","modification":"2025-04-18T15:15:18.034Z","creation":"2019-03-27T02:03:16Z"},"accession":"S-EPMC1782362","cross_references":{"pubmed":["17170707"],"doi":["10.1038/sj.emboj.7601475"]}}