biostudies-literatureUnknown80(2)Laumonnier FWellcome TrustBeyond finding individual genes that are involved in medical disorders, an important challenge is the integration of sets of disease genes with the complexities of basic biological processes. We examine this issue by focusing on neuronal multiprotein complexes and their components encoded on the human X chromosome. Multiprotein signaling complexes in the postsynaptic terminal of central nervous system synapses are essential for the induction of neuronal plasticity and cognitive processes in animals. The prototype complex is the N-methyl-D-aspartate receptor complex/membrane-associated guanylate kinase-associated signaling complex (NRC/MASC) comprising 185 proteins and embedded within the postsynaptic density (PSD), which is a set of complexes totaling approximately 1,100 proteins. It is stAmerican journal of human genetics205-20https://www.ebi.ac.uk/biostudies/studies/S-EPMC1785339biostudies-literatureThe role of neuronal complexes in human X-linked brain diseases.PMC1785339Cuthbert PCGrant SGLaumonnier FfalseThe role of neuronal complexes in human X-linked brain diseases.Beyond finding individual genes that are involved in medical disorders, an important challenge is the integration of sets of disease genes with the complexities of basic biological processes. We examine this issue by focusing on neuronal multiprotein complexes and their components encoded on the human X chromosome. Multiprotein signaling complexes in the postsynaptic terminal of central nervous system synapses are essential for the induction of neuronal plasticity and cognitive processes in animals. The prototype complex is the N-methyl-D-aspartate receptor complex/membrane-associated guanylate kinase-associated signaling complex (NRC/MASC) comprising 185 proteins and embedded within the postsynaptic density (PSD), which is a set of complexes totaling approximately 1,100 proteins. It is st2007-01-01T00:00:00Z2007 Feb2025-04-18T20:16:19.621Z2019-03-27T02:03:20ZS-EPMC17853391723612710.1086/511441