{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["96(20)"],"submitter":["Senaldi G"],"pubmed_abstract":["We have identified a cytokine of the IL-6 family and named it novel neurotrophin-1/B cell-stimulating factor-3 (NNT-1/BSF-3). NNT-1/BSF-3 cDNA was cloned from activated Jurkat human T cell lymphoma cells. Its sequence predicts a 225-aa protein with a 27-aa signal peptide, a molecular mass of 22 kDa in mature form, and the highest homology to cardiotrophin-1 and ciliary neurotrophic factor. The gene for NNT-1/BSF-3 is on chromosome 11q13. A murine equivalent to NNT-1/BSF-3 also was identified, which shows 96% homology to human NNT-1/BSF-3. NNT-1/BSF-3 mRNA is found mainly in lymph nodes and spleen. NNT-1/BSF-3 induces tyrosine phosphorylation of glycoprotein 130 (gp130), leukemia inhibitory factor receptor beta, and signal transducer and activator of transcription 3 in the SK-N-MC human neu"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pagination":["11458-63"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC18055"],"repository":["biostudies-literature"],"pubmed_title":["Novel neurotrophin-1/B cell-stimulating factor-3: a cytokine of the IL-6 family."],"pmcid":["PMC18055"],"pubmed_authors":["Elliott G","Sarmiento U","Senaldi G","Lile J","Freeman D","Chang MS","Shaklee CL","Manu F","Varnum BC","Scully S","Guo J","McNinch J","Starnes C","Simonet WS","Boone T"],"additional_accession":[]},"is_claimable":false,"name":"Novel neurotrophin-1/B cell-stimulating factor-3: a cytokine of the IL-6 family.","description":"We have identified a cytokine of the IL-6 family and named it novel neurotrophin-1/B cell-stimulating factor-3 (NNT-1/BSF-3). NNT-1/BSF-3 cDNA was cloned from activated Jurkat human T cell lymphoma cells. Its sequence predicts a 225-aa protein with a 27-aa signal peptide, a molecular mass of 22 kDa in mature form, and the highest homology to cardiotrophin-1 and ciliary neurotrophic factor. The gene for NNT-1/BSF-3 is on chromosome 11q13. A murine equivalent to NNT-1/BSF-3 also was identified, which shows 96% homology to human NNT-1/BSF-3. NNT-1/BSF-3 mRNA is found mainly in lymph nodes and spleen. NNT-1/BSF-3 induces tyrosine phosphorylation of glycoprotein 130 (gp130), leukemia inhibitory factor receptor beta, and signal transducer and activator of transcription 3 in the SK-N-MC human neu","dates":{"release":"1999-01-01T00:00:00Z","publication":"1999 Sep","modification":"2025-04-04T22:05:41.761Z","creation":"2019-03-27T00:17:45Z"},"accession":"S-EPMC18055","cross_references":{"pubmed":["10500198"],"doi":["10.1073/pnas.96.20.11458"]}}