biostudies-literatureUnknown96(20)Senaldi GWe have identified a cytokine of the IL-6 family and named it novel neurotrophin-1/B cell-stimulating factor-3 (NNT-1/BSF-3). NNT-1/BSF-3 cDNA was cloned from activated Jurkat human T cell lymphoma cells. Its sequence predicts a 225-aa protein with a 27-aa signal peptide, a molecular mass of 22 kDa in mature form, and the highest homology to cardiotrophin-1 and ciliary neurotrophic factor. The gene for NNT-1/BSF-3 is on chromosome 11q13. A murine equivalent to NNT-1/BSF-3 also was identified, which shows 96% homology to human NNT-1/BSF-3. NNT-1/BSF-3 mRNA is found mainly in lymph nodes and spleen. NNT-1/BSF-3 induces tyrosine phosphorylation of glycoprotein 130 (gp130), leukemia inhibitory factor receptor beta, and signal transducer and activator of transcription 3 in the SK-N-MC human neuProceedings of the National Academy of Sciences of the United States of America11458-63https://www.ebi.ac.uk/biostudies/studies/S-EPMC18055biostudies-literatureNovel neurotrophin-1/B cell-stimulating factor-3: a cytokine of the IL-6 family.PMC18055Elliott GSarmiento USenaldi GLile JFreeman DChang MSShaklee CLManu FVarnum BCScully SGuo JMcNinch JStarnes CSimonet WSBoone TfalseNovel neurotrophin-1/B cell-stimulating factor-3: a cytokine of the IL-6 family.We have identified a cytokine of the IL-6 family and named it novel neurotrophin-1/B cell-stimulating factor-3 (NNT-1/BSF-3). NNT-1/BSF-3 cDNA was cloned from activated Jurkat human T cell lymphoma cells. Its sequence predicts a 225-aa protein with a 27-aa signal peptide, a molecular mass of 22 kDa in mature form, and the highest homology to cardiotrophin-1 and ciliary neurotrophic factor. The gene for NNT-1/BSF-3 is on chromosome 11q13. A murine equivalent to NNT-1/BSF-3 also was identified, which shows 96% homology to human NNT-1/BSF-3. NNT-1/BSF-3 mRNA is found mainly in lymph nodes and spleen. NNT-1/BSF-3 induces tyrosine phosphorylation of glycoprotein 130 (gp130), leukemia inhibitory factor receptor beta, and signal transducer and activator of transcription 3 in the SK-N-MC human neu1999-01-01T00:00:00Z1999 Sep2025-04-04T22:05:41.761Z2019-03-27T00:17:45ZS-EPMC180551050019810.1073/pnas.96.20.11458