{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chakrabarty A"],"funding":["NICHD NIH HHS"],"pagination":["14"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC1817651"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8"],"pubmed_abstract":["Background
The trophoblast Kunitz domain proteins (TKDPs) constitute a highly expressed, placenta-specific, multigene family restricted to ruminant ungulates and characterized by a C-terminal \"Kunitz\" domain, preceded by one or more unique N-terminal domains. TKDP-1 shares an almost identical expression pattern with interferon-tau, the \"maternal recognition of pregnancy protein\" in ruminants. Our goal here has been to determine whether the ovine (ov) Tkdp-1 and IFNT genes possess a similar transcriptional code.Results
The ovTkdp-1 promoter has been cloned and characterized. As with the IFNT promoter, the Tkdp-1 promoter is responsive to Ets-2, and promoter-driven reporter activity can be increased over 700-fold in response to over-expression of Ets-2 and a constitutively ac"],"journal":["BMC molecular biology"],"pubmed_title":["Ets-2 and C/EBP-beta are important mediators of ovine trophoblast Kunitz domain protein-1 gene expression in trophoblast."],"pmcid":["PMC1817651"],"funding_grant_id":["R01 HD042201","R01 HD21896","R01 HD021896","R01 HD42201"],"pubmed_authors":["Chakrabarty A","Roberts MR"],"additional_accession":[]},"is_claimable":false,"name":"Ets-2 and C/EBP-beta are important mediators of ovine trophoblast Kunitz domain protein-1 gene expression in trophoblast.","description":"Background
The trophoblast Kunitz domain proteins (TKDPs) constitute a highly expressed, placenta-specific, multigene family restricted to ruminant ungulates and characterized by a C-terminal \"Kunitz\" domain, preceded by one or more unique N-terminal domains. TKDP-1 shares an almost identical expression pattern with interferon-tau, the \"maternal recognition of pregnancy protein\" in ruminants. Our goal here has been to determine whether the ovine (ov) Tkdp-1 and IFNT genes possess a similar transcriptional code.Results
The ovTkdp-1 promoter has been cloned and characterized. As with the IFNT promoter, the Tkdp-1 promoter is responsive to Ets-2, and promoter-driven reporter activity can be increased over 700-fold in response to over-expression of Ets-2 and a constitutively ac","dates":{"release":"2007-01-01T00:00:00Z","publication":"2007 Feb","modification":"2026-07-15T03:55:01.201Z","creation":"2025-08-30T03:09:48.387Z"},"accession":"S-EPMC1817651","cross_references":{"pubmed":["17326832"],"doi":["10.1186/1471-2199-8-14"]}}