biostudies-literaturePerez GINIA NIH HHS5229-34https://www.ebi.ac.uk/biostudies/studies/S-EPMC1817832biostudies-literatureUnknown104(12)The menopausal transition in human females, which is driven by a loss of cyclic ovarian function, occurs around age 50 and is thought to underlie the emergence of an array of health problems in aging women. Although mice do not undergo a true menopause, female mice exhibit ovarian failure long before death because of chronological age and subsequently develop many of the same age-associated health complications observed in postmenopausal women. Here we show in mice that inactivation of the proapoptotic Bax gene, which sustains ovarian lifespan into advanced age, extends fertile potential and minimizes many age-related health problems, including bone and muscle loss, excess fat deposition, alopecia, cataracts, deafness, increased anxiety, and selective attention deficit. Further, ovariectomProceedings of the National Academy of Sciences of the United States of AmericaAbsence of the proapoptotic Bax protein extends fertility and alleviates age-related health complications in female mice.PMC1817832R01/R37-AG012279R37 AG012279R01 AG012279Grynpas MHunt PPerez GIWise LBechard ARoder JKanisek MTilly JLLipina TJurisicova ATakai YfalseAbsence of the proapoptotic Bax protein extends fertility and alleviates age-related health complications in female mice.The menopausal transition in human females, which is driven by a loss of cyclic ovarian function, occurs around age 50 and is thought to underlie the emergence of an array of health problems in aging women. Although mice do not undergo a true menopause, female mice exhibit ovarian failure long before death because of chronological age and subsequently develop many of the same age-associated health complications observed in postmenopausal women. Here we show in mice that inactivation of the proapoptotic Bax gene, which sustains ovarian lifespan into advanced age, extends fertile potential and minimizes many age-related health problems, including bone and muscle loss, excess fat deposition, alopecia, cataracts, deafness, increased anxiety, and selective attention deficit. Further, ovariectom2007-01-01T00:00:00Z2007 Mar2025-04-05T10:04:51.33Z2019-03-27T02:03:32ZS-EPMC18178321736038910.1073/pnas.0608557104