{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["5(4)"],"submitter":["Momose T"],"pubmed_abstract":["In phylogenetically diverse animals, including the basally diverging cnidarians, \"determinants\" localised within the egg are responsible for directing development of the embryonic body plan. Many such determinants are known to regulate the Wnt signalling pathway, leading to regionalised stabilisation of the transcriptional coregulator beta-catenin; however, the only strong molecular candidate for a Wnt-activating determinant identified to date is the ligand Wnt11 in Xenopus. We have identified embryonic \"oral-aboral\" axis determinants in the cnidarian Clytia hemisphaerica in the form of RNAs encoding two Frizzled family Wnt receptors, localised at opposite poles of the egg. Morpholino-mediated inhibition of translation showed that CheFz1, localised at the animal pole, activates the canonic"],"journal":["PLoS biology"],"pagination":["e70"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC1820609"],"repository":["biostudies-literature"],"pubmed_title":["Two oppositely localised frizzled RNAs as axis determinants in a cnidarian embryo."],"pmcid":["PMC1820609"],"pubmed_authors":["Houliston E","Momose T"],"additional_accession":[]},"is_claimable":false,"name":"Two oppositely localised frizzled RNAs as axis determinants in a cnidarian embryo.","description":"In phylogenetically diverse animals, including the basally diverging cnidarians, \"determinants\" localised within the egg are responsible for directing development of the embryonic body plan. Many such determinants are known to regulate the Wnt signalling pathway, leading to regionalised stabilisation of the transcriptional coregulator beta-catenin; however, the only strong molecular candidate for a Wnt-activating determinant identified to date is the ligand Wnt11 in Xenopus. We have identified embryonic \"oral-aboral\" axis determinants in the cnidarian Clytia hemisphaerica in the form of RNAs encoding two Frizzled family Wnt receptors, localised at opposite poles of the egg. Morpholino-mediated inhibition of translation showed that CheFz1, localised at the animal pole, activates the canonic","dates":{"release":"2007-01-01T00:00:00Z","publication":"2007 Apr","modification":"2025-06-01T01:11:13.026Z","creation":"2019-03-27T02:03:32Z"},"accession":"S-EPMC1820609","cross_references":{"pubmed":["17355179"],"doi":["10.1371/journal.pbio.0050070"]}}