{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Perreau VM"],"funding":["NIA NIH HHS","NIEHS NIH HHS"],"pagination":["22-31"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC1847646"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["182(1-2)"],"pubmed_abstract":["Melatonin modulates the expression of a number of genes related to inflammation and immunity. Declining levels of melatonin with age may thus relate to some of the changes in immune function that occur with age. mRNA expression levels in murine CNS were measured using oligonucleotide microarrays in order to determine whether a dietary melatonin supplement may modify age-related changes in the response to an inflammatory challenge. CB6F1 male mice were fed 40-ppm melatonin for 9 weeks prior to sacrifice at 26.5 months of age, and compared with age-matched untreated controls and 4.5-month-old controls. A subset of both young and old animals was injected i.p. with lipopolysaccharide (LPS). After 3 h, total RNA was extracted from whole brain (excluding brain stem and cerebellum), and individua"],"journal":["Journal of neuroimmunology"],"pubmed_title":["Melatonin treatment in old mice enables a more youthful response to LPS in the brain."],"pmcid":["PMC1847646"],"funding_grant_id":["ES 7992","R01 AG016794","AG14882","R01 AG018884","R01 ES007992","AG 16794","AG18884"],"pubmed_authors":["Sharman EH","Bondy SC","Perreau VM","Sharman KG","Cotman CW"],"additional_accession":[]},"is_claimable":false,"name":"Melatonin treatment in old mice enables a more youthful response to LPS in the brain.","description":"Melatonin modulates the expression of a number of genes related to inflammation and immunity. Declining levels of melatonin with age may thus relate to some of the changes in immune function that occur with age. mRNA expression levels in murine CNS were measured using oligonucleotide microarrays in order to determine whether a dietary melatonin supplement may modify age-related changes in the response to an inflammatory challenge. CB6F1 male mice were fed 40-ppm melatonin for 9 weeks prior to sacrifice at 26.5 months of age, and compared with age-matched untreated controls and 4.5-month-old controls. A subset of both young and old animals was injected i.p. with lipopolysaccharide (LPS). After 3 h, total RNA was extracted from whole brain (excluding brain stem and cerebellum), and individua","dates":{"release":"2007-01-01T00:00:00Z","publication":"2007 Jan","modification":"2025-04-18T17:46:56.294Z","creation":"2019-03-27T02:03:42Z"},"accession":"S-EPMC1847646","cross_references":{"pubmed":["17070935"],"doi":["10.1016/j.jneuroim.2006.09.005"]}}