biostudies-literatureUnknown159(1)Sanchez-Beato MDifferent studies have already shown that the isolated inactivation of p21, p16, or p27 cyclin-dependent kinase inhibitors (CKIs) is associated with increased growth fraction, tumor progression, or decreased overall survival in cases of non-Hodgkin's lymphoma. In this study we linked molecular study of the p53 and p16 genes with immunohistochemical analysis of p27 expression in a group of aggressive B-cell lymphomas [large B-cell lymphomas (LBCLs) and Burkitt's lymphomas]. This was done to analyze the relationship between p53 and p16 silencing, p27 anomalous overexpression, and clinical follow-up, testing the hypothesis that the accumulation of CKI alterations could confer to the tumors a higher aggressivity. In a group of 62 patients, p53 inactivation as a result of mutation was observed The American journal of pathology205-13https://www.ebi.ac.uk/biostudies/studies/S-EPMC1850429biostudies-literatureOverall survival in aggressive B-cell lymphomas is dependent on the accumulation of alterations in p53, p16, and p27.PMC1850429Piris MASanchez-Beato MCamacho FVilluendas RSaez AISanchez EAlgara PSanchez-Aguilera ANavas ICSol Mateo MfalseOverall survival in aggressive B-cell lymphomas is dependent on the accumulation of alterations in p53, p16, and p27.Different studies have already shown that the isolated inactivation of p21, p16, or p27 cyclin-dependent kinase inhibitors (CKIs) is associated with increased growth fraction, tumor progression, or decreased overall survival in cases of non-Hodgkin's lymphoma. In this study we linked molecular study of the p53 and p16 genes with immunohistochemical analysis of p27 expression in a group of aggressive B-cell lymphomas [large B-cell lymphomas (LBCLs) and Burkitt's lymphomas]. This was done to analyze the relationship between p53 and p16 silencing, p27 anomalous overexpression, and clinical follow-up, testing the hypothesis that the accumulation of CKI alterations could confer to the tumors a higher aggressivity. In a group of 62 patients, p53 inactivation as a result of mutation was observed 2001-01-01T00:00:00Z2001 Jul2025-04-26T03:11:16.67Z2019-06-06T13:37:49ZS-EPMC18504291143846710.1016/S0002-9440(10)61686-0