{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["3"],"submitter":["Daugaard L"],"pubmed_abstract":["<h4>Background</h4>Desmoglein 1 (DSG1) is the target protein in the skin disease exudative epidermitis in pigs caused by virulent strains of Staphylococcus hyicus. The exfoliative toxins produced by S. hyicus digest the porcine desmoglein 1 (PIG)DSG1 by a very specific reaction. This study investigated the location of single nucleotide polymorphisms (SNPs) in the porcine desmoglein 1 gene (PIG)DSG1 in correlation to the cleavage site as well as if the genotype of the SNPs is correlated to susceptibility or resistance to the disease.<h4>Results</h4>DNA from 32 affected and 32 unaffected piglets with exudative epidermitis were diagnosed clinically as affected or unaffected. Two regions of the desmoglein 1 gene were sequenced and genotypes of the SNPs were established. Seven SNPs (823T>C, 828"],"journal":["BMC veterinary research"],"pagination":["4"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC1858681"],"repository":["biostudies-literature"],"pubmed_title":["Investigation of SNPs in the porcine desmoglein 1 gene."],"pmcid":["PMC1858681"],"pubmed_authors":["Daugaard L","Andresen LO","Fredholm M"],"additional_accession":[]},"is_claimable":false,"name":"Investigation of SNPs in the porcine desmoglein 1 gene.","description":"<h4>Background</h4>Desmoglein 1 (DSG1) is the target protein in the skin disease exudative epidermitis in pigs caused by virulent strains of Staphylococcus hyicus. The exfoliative toxins produced by S. hyicus digest the porcine desmoglein 1 (PIG)DSG1 by a very specific reaction. This study investigated the location of single nucleotide polymorphisms (SNPs) in the porcine desmoglein 1 gene (PIG)DSG1 in correlation to the cleavage site as well as if the genotype of the SNPs is correlated to susceptibility or resistance to the disease.<h4>Results</h4>DNA from 32 affected and 32 unaffected piglets with exudative epidermitis were diagnosed clinically as affected or unaffected. Two regions of the desmoglein 1 gene were sequenced and genotypes of the SNPs were established. Seven SNPs (823T>C, 828","dates":{"release":"2007-01-01T00:00:00Z","publication":"2007 Mar","modification":"2025-04-04T07:41:46.13Z","creation":"2019-03-27T02:03:52Z"},"accession":"S-EPMC1858681","cross_references":{"pubmed":["17397555"],"doi":["10.1186/1746-6148-3-4"]}}