{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Peng X"],"funding":["NCI NIH HHS"],"pagination":["446-50"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC1868542"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["103(3-5)"],"pubmed_abstract":["Our previous microarray analysis showed that N-methyl-N-nitrosourea (MNU) transformed MCF12F breast epithelial cells exhibited upregulation of several genes, including prohibitin, which was reversed by 1alpha-hydroxyvitamin D(5) (1alpha(OH)D(5)) treatment. The in silico screening for putative transcription factor binding sites identified two VDR/RXR binding sites in the 1kb promoter region of prohibitin. Other binding sites for EGR and GR which are also Vitamin D target genes were identified in this region, indicating that prohibitin is a potential target gene for Vitamin D. The combination of multiple binding sites also provides a basis for a possible dual regulation of prohibitin by Vitamin D. Prohibitin upregulation by 1alpha(OH)D(5) treatment at both transcription and translation level"],"journal":["The Journal of steroid biochemistry and molecular biology"],"pubmed_title":["Differential expression of prohibitin is correlated with dual action of Vitamin D as a proliferative and antiproliferative hormone in breast epithelial cells."],"pmcid":["PMC1868542"],"funding_grant_id":["CA 82316","R01 CA082316"],"pubmed_authors":["Peng X","Mehta RG"],"additional_accession":[]},"is_claimable":false,"name":"Differential expression of prohibitin is correlated with dual action of Vitamin D as a proliferative and antiproliferative hormone in breast epithelial cells.","description":"Our previous microarray analysis showed that N-methyl-N-nitrosourea (MNU) transformed MCF12F breast epithelial cells exhibited upregulation of several genes, including prohibitin, which was reversed by 1alpha-hydroxyvitamin D(5) (1alpha(OH)D(5)) treatment. The in silico screening for putative transcription factor binding sites identified two VDR/RXR binding sites in the 1kb promoter region of prohibitin. Other binding sites for EGR and GR which are also Vitamin D target genes were identified in this region, indicating that prohibitin is a potential target gene for Vitamin D. The combination of multiple binding sites also provides a basis for a possible dual regulation of prohibitin by Vitamin D. Prohibitin upregulation by 1alpha(OH)D(5) treatment at both transcription and translation level","dates":{"release":"2007-01-01T00:00:00Z","publication":"2007 Mar","modification":"2025-04-05T08:51:05.725Z","creation":"2019-06-06T14:21:07Z"},"accession":"S-EPMC1868542","cross_references":{"pubmed":["17207617"],"doi":["10.1016/j.jsbmb.2006.11.017"]}}