{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["54(6)"],"submitter":["Gerloff T"],"pubmed_abstract":["AIMS:A noncoding single nucleotide polymorphism (SNP) in exon 26 3435C > T of the highly polymorphic MDR1 gene has been demonstrated to alter digoxin absorption after induction of the MDR1 gene product P-glycoprotein by rifampicin or after multiple oral dosing. The aim of the study was to investigate the effects of the major known MDR1 SNPs on the absorption of digoxin after a single oral dose in a large sample without drug pretreatment. METHODS:Fifty healthy white male subjects between the age of 18 and 40 years were enrolled. Following an overnight fast, all subjects received a single oral dose of 1 mg digoxin. Venous blood samples were taken at intervals up to 4 h post dose to obtain a pharmacokinetic profile. RESULTS:AUC(0,4 h), Cmax and tmax, used as indices of digoxin absorption, wer"],"journal":["British journal of clinical pharmacology"],"pagination":["610-6"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC1874502"],"repository":["biostudies-literature"],"pubmed_title":["MDR1 genotypes do not influence the absorption of a single oral dose of 1 mg digoxin in healthy white males."],"pmcid":["PMC1874502"],"pubmed_authors":["Roots I","Gerloff T","Cascorbi I","Schaefer M","Meisel C","Oselin K","Johne A"],"additional_accession":[]},"is_claimable":false,"name":"MDR1 genotypes do not influence the absorption of a single oral dose of 1 mg digoxin in healthy white males.","description":"AIMS:A noncoding single nucleotide polymorphism (SNP) in exon 26 3435C > T of the highly polymorphic MDR1 gene has been demonstrated to alter digoxin absorption after induction of the MDR1 gene product P-glycoprotein by rifampicin or after multiple oral dosing. The aim of the study was to investigate the effects of the major known MDR1 SNPs on the absorption of digoxin after a single oral dose in a large sample without drug pretreatment. METHODS:Fifty healthy white male subjects between the age of 18 and 40 years were enrolled. Following an overnight fast, all subjects received a single oral dose of 1 mg digoxin. Venous blood samples were taken at intervals up to 4 h post dose to obtain a pharmacokinetic profile. RESULTS:AUC(0,4 h), Cmax and tmax, used as indices of digoxin absorption, wer","dates":{"release":"2002-01-01T00:00:00Z","publication":"2002 Dec","modification":"2025-04-19T17:27:04.406Z","creation":"2019-03-27T02:03:59Z"},"accession":"S-EPMC1874502","cross_references":{"pubmed":["12492608"],"doi":["10.1046/j.1365-2125.2002.01691.x"]}}