biostudies-literatureUnknown54(6)Gerloff TAIMS:A noncoding single nucleotide polymorphism (SNP) in exon 26 3435C > T of the highly polymorphic MDR1 gene has been demonstrated to alter digoxin absorption after induction of the MDR1 gene product P-glycoprotein by rifampicin or after multiple oral dosing. The aim of the study was to investigate the effects of the major known MDR1 SNPs on the absorption of digoxin after a single oral dose in a large sample without drug pretreatment. METHODS:Fifty healthy white male subjects between the age of 18 and 40 years were enrolled. Following an overnight fast, all subjects received a single oral dose of 1 mg digoxin. Venous blood samples were taken at intervals up to 4 h post dose to obtain a pharmacokinetic profile. RESULTS:AUC(0,4 h), Cmax and tmax, used as indices of digoxin absorption, werBritish journal of clinical pharmacology610-6https://www.ebi.ac.uk/biostudies/studies/S-EPMC1874502biostudies-literatureMDR1 genotypes do not influence the absorption of a single oral dose of 1 mg digoxin in healthy white males.PMC1874502Roots IGerloff TCascorbi ISchaefer MMeisel COselin KJohne AfalseMDR1 genotypes do not influence the absorption of a single oral dose of 1 mg digoxin in healthy white males.AIMS:A noncoding single nucleotide polymorphism (SNP) in exon 26 3435C > T of the highly polymorphic MDR1 gene has been demonstrated to alter digoxin absorption after induction of the MDR1 gene product P-glycoprotein by rifampicin or after multiple oral dosing. The aim of the study was to investigate the effects of the major known MDR1 SNPs on the absorption of digoxin after a single oral dose in a large sample without drug pretreatment. METHODS:Fifty healthy white male subjects between the age of 18 and 40 years were enrolled. Following an overnight fast, all subjects received a single oral dose of 1 mg digoxin. Venous blood samples were taken at intervals up to 4 h post dose to obtain a pharmacokinetic profile. RESULTS:AUC(0,4 h), Cmax and tmax, used as indices of digoxin absorption, wer2002-01-01T00:00:00Z2002 Dec2025-04-19T17:27:04.406Z2019-03-27T02:03:59ZS-EPMC18745021249260810.1046/j.1365-2125.2002.01691.x