{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Luther SA"],"funding":["NIAID NIH HHS"],"pagination":["12694-9"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC18826"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["97(23)"],"pubmed_abstract":["The spontaneous mutant mouse strain, plt/plt, lacks the secondary lymphoid organ chemokine (SLC)-ser gene and has disrupted trafficking of T cells and dendritic cells (DCs) to lymphoid tissues. We demonstrate here that the gene for the related chemokine, Epstein-Barr virus-induced molecule-1 ligand chemokine (ELC), is also deleted in this immunodeficient mouse strain. Using a combination of approaches, including bone marrow reconstitution and double in situ hybridization, we show in wild-type mice that ELC is expressed by T zone stromal cells that also make SLC. Smaller amounts of ELC are made by DCs, predominantly of the CD8(+) phenotype. We propose that ELC- and SLC-expressing T zone stromal cells play a central role in bringing naive T cells and DCs together for the initiation of immune"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Coexpression of the chemokines ELC and SLC by T zone stromal cells and deletion of the ELC gene in the plt/plt mouse."],"pmcid":["PMC18826"],"funding_grant_id":["R01 AI045073","AI45073"],"pubmed_authors":["Tang HL","Cyster JG","Hyman PL","Luther SA","Farr AG"],"additional_accession":[]},"is_claimable":false,"name":"Coexpression of the chemokines ELC and SLC by T zone stromal cells and deletion of the ELC gene in the plt/plt mouse.","description":"The spontaneous mutant mouse strain, plt/plt, lacks the secondary lymphoid organ chemokine (SLC)-ser gene and has disrupted trafficking of T cells and dendritic cells (DCs) to lymphoid tissues. We demonstrate here that the gene for the related chemokine, Epstein-Barr virus-induced molecule-1 ligand chemokine (ELC), is also deleted in this immunodeficient mouse strain. Using a combination of approaches, including bone marrow reconstitution and double in situ hybridization, we show in wild-type mice that ELC is expressed by T zone stromal cells that also make SLC. Smaller amounts of ELC are made by DCs, predominantly of the CD8(+) phenotype. We propose that ELC- and SLC-expressing T zone stromal cells play a central role in bringing naive T cells and DCs together for the initiation of immune","dates":{"release":"2000-01-01T00:00:00Z","publication":"2000 Nov","modification":"2025-04-04T22:06:25.574Z","creation":"2019-03-26T23:45:22Z"},"accession":"S-EPMC18826","cross_references":{"pubmed":["11070085"],"doi":["10.1073/pnas.97.23.12694"]}}