{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["3"],"submitter":["Ghozlan SA"],"pubmed_abstract":["3-Oxo-2-arylhydrazononitriles 1a-c react readily with chloroacetonitrile, ethyl chloroacetate, and with phenacyl chloride to give 4-aminopyrazoles 4a-e. The pyrazolo[4,3-d]pyrimidine derivatives 7 and 10 are synthesized via reaction of the aminopyrazole 4b with phenylisothiocyanate and DMFDMA/NH4OAc respectively."],"journal":["Beilstein journal of organic chemistry"],"pagination":["15"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC1885264"],"repository":["biostudies-literature"],"pubmed_title":["An easy synthesis of 5-functionally substituted ethyl 4-amino-1-aryl- pyrazolo-3-carboxylates: interesting precursors to sildenafil analogues."],"pmcid":["PMC1885264"],"pubmed_authors":["Abdelhamid IA","Ghozlan SA","Badahdah KO"],"additional_accession":[]},"is_claimable":false,"name":"An easy synthesis of 5-functionally substituted ethyl 4-amino-1-aryl- pyrazolo-3-carboxylates: interesting precursors to sildenafil analogues.","description":"3-Oxo-2-arylhydrazononitriles 1a-c react readily with chloroacetonitrile, ethyl chloroacetate, and with phenacyl chloride to give 4-aminopyrazoles 4a-e. The pyrazolo[4,3-d]pyrimidine derivatives 7 and 10 are synthesized via reaction of the aminopyrazole 4b with phenylisothiocyanate and DMFDMA/NH4OAc respectively.","dates":{"release":"2007-01-01T00:00:00Z","publication":"2007 May","modification":"2026-03-16T16:09:54.273Z","creation":"2019-03-27T02:04:02Z"},"accession":"S-EPMC1885264","cross_references":{"pubmed":["17470302"],"doi":["10.1186/1860-5397-3-15"]}}