{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pluskota E"],"funding":["NIDDK NIH HHS","NHLBI NIH HHS"],"pagination":["3970-8"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC1895095"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["106(12)"],"pubmed_abstract":["High-throughput genomic technology identified an association between a single nucleotide polymorphism (SNP), a proline (P387) rather than the predominant alanine (A387) at position 387 in thrombospondin-4 (TSP-4) and premature myocardial infarction. The inflammatory hypothesis of atherosclerosis invokes a prominent role of leukocytes and cytokines in pathogenesis. As the expression of TSP-4 by vascular cells permits its exposure to circulating leukocytes, the interactions of human neutrophils (polymorphonuclear leukocytes [PMNs]) with both TSP-4 variants were investigated. Phorbol 12-myristate 13-acetate (PMA)-stimulated PMNs adhered and migrated well and equally on the TSP-4 variants. Integrin alpha(M)beta2 was identified as the TSP-4 receptor mediating these responses, and the 3 epiderma"],"journal":["Blood"],"pubmed_title":["Mechanism and effect of thrombospondin-4 polymorphisms on neutrophil function."],"pmcid":["PMC1895095"],"funding_grant_id":["R01 HL 66197","K01DK62128","P50 HL-077107"],"pubmed_authors":["Pluskota E","Topol EJ","Stenina OI","Krukovets I","Szpak D","Plow EF"],"additional_accession":[]},"is_claimable":false,"name":"Mechanism and effect of thrombospondin-4 polymorphisms on neutrophil function.","description":"High-throughput genomic technology identified an association between a single nucleotide polymorphism (SNP), a proline (P387) rather than the predominant alanine (A387) at position 387 in thrombospondin-4 (TSP-4) and premature myocardial infarction. The inflammatory hypothesis of atherosclerosis invokes a prominent role of leukocytes and cytokines in pathogenesis. As the expression of TSP-4 by vascular cells permits its exposure to circulating leukocytes, the interactions of human neutrophils (polymorphonuclear leukocytes [PMNs]) with both TSP-4 variants were investigated. Phorbol 12-myristate 13-acetate (PMA)-stimulated PMNs adhered and migrated well and equally on the TSP-4 variants. Integrin alpha(M)beta2 was identified as the TSP-4 receptor mediating these responses, and the 3 epiderma","dates":{"release":"2005-01-01T00:00:00Z","publication":"2005 Dec","modification":"2025-04-22T04:48:59.163Z","creation":"2019-06-06T14:37:01Z"},"accession":"S-EPMC1895095","cross_references":{"pubmed":["16099885"],"doi":["10.1182/blood-2005-03-1292"]}}