{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Riddick G"],"funding":["NCRR NIH HHS","NIGMS NIH HHS"],"pagination":["118"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC1911202"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["3"],"pubmed_abstract":["Although there exists a large family of nuclear transport receptors (Karyopherins), the majority of known import cargoes use an adapter protein, Importin-alpha (Impalpha), which links the cargo to a karyopherin, Importin-beta (Impbeta). The reason for the existence of transport adapters is unknown. One hypothesis is that, as Impalpha re-export is coupled to GTP hydrolysis, it can drive a higher concentration of nuclear cargo than could be achieved by direct cargo binding to Importin-beta. However, computer simulations predicted the opposite outcome, and showed that direct transport is faster than adapter-mediated transport. These predictions were validated experimentally. The data, together with previous analyses of nuclear protein import, suggest that the use of adapters such as importin-alpha provides the cell with increased dynamic range for control of nuclear import rates, but at the expense of efficiency."],"journal":["Molecular systems biology"],"pubmed_title":["The adapter importin-alpha provides flexible control of nuclear import at the expense of efficiency."],"pmcid":["PMC1911202"],"funding_grant_id":["U54 RR022232","R01 GM050526","GM50525","U54 RR 022232"],"pubmed_authors":["Riddick G","Macara IG"],"additional_accession":[]},"is_claimable":false,"name":"The adapter importin-alpha provides flexible control of nuclear import at the expense of efficiency.","description":"Although there exists a large family of nuclear transport receptors (Karyopherins), the majority of known import cargoes use an adapter protein, Importin-alpha (Impalpha), which links the cargo to a karyopherin, Importin-beta (Impbeta). The reason for the existence of transport adapters is unknown. One hypothesis is that, as Impalpha re-export is coupled to GTP hydrolysis, it can drive a higher concentration of nuclear cargo than could be achieved by direct cargo binding to Importin-beta. However, computer simulations predicted the opposite outcome, and showed that direct transport is faster than adapter-mediated transport. These predictions were validated experimentally. The data, together with previous analyses of nuclear protein import, suggest that the use of adapters such as importin-alpha provides the cell with increased dynamic range for control of nuclear import rates, but at the expense of efficiency.","dates":{"release":"2007-01-01T00:00:00Z","publication":"2007","modification":"2025-04-19T13:09:51.041Z","creation":"2019-03-27T02:04:18Z"},"accession":"S-EPMC1911202","cross_references":{"pubmed":["17551513"],"doi":["10.1038/msb4100160"]}}