{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8"],"submitter":["Gonzalez AM"],"pubmed_abstract":["<h4>Background</h4>The out of Africa hypothesis has gained generalized consensus. However, many specific questions remain unsettled. To know whether the two M and N macrohaplogroups that colonized Eurasia were already present in Africa before the exit is puzzling. It has been proposed that the east African clade M1 supports a single origin of haplogroup M in Africa. To test the validity of that hypothesis, the phylogeographic analysis of 13 complete mitochondrial DNA (mtDNA) sequences and 261 partial sequences belonging to haplogroup M1 was carried out.<h4>Results</h4>The coalescence age of the African haplogroup M1 is younger than those for other M Asiatic clades. In contradiction to the hypothesis of an eastern Africa origin for modern human expansions out of Africa, the most ancestral M"],"journal":["BMC genomics"],"pagination":["223"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC1945034"],"repository":["biostudies-literature"],"pubmed_title":["Mitochondrial lineage M1 traces an early human backflow to Africa."],"pmcid":["PMC1945034"],"pubmed_authors":["Gonzalez AM","Pestano J","Abu-Amero KK","Cabrera VM","Larruga JM","Shi Y"],"additional_accession":[]},"is_claimable":false,"name":"Mitochondrial lineage M1 traces an early human backflow to Africa.","description":"<h4>Background</h4>The out of Africa hypothesis has gained generalized consensus. However, many specific questions remain unsettled. To know whether the two M and N macrohaplogroups that colonized Eurasia were already present in Africa before the exit is puzzling. It has been proposed that the east African clade M1 supports a single origin of haplogroup M in Africa. To test the validity of that hypothesis, the phylogeographic analysis of 13 complete mitochondrial DNA (mtDNA) sequences and 261 partial sequences belonging to haplogroup M1 was carried out.<h4>Results</h4>The coalescence age of the African haplogroup M1 is younger than those for other M Asiatic clades. In contradiction to the hypothesis of an eastern Africa origin for modern human expansions out of Africa, the most ancestral M","dates":{"release":"2007-01-01T00:00:00Z","publication":"2007 Jul","modification":"2026-03-31T11:16:54.356Z","creation":"2019-03-27T02:21:16Z"},"accession":"S-EPMC1945034","cross_references":{"pubmed":["17620140"],"doi":["10.1186/1471-2164-8-223"]}}